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Literature DB >> 24772236

Enhancing the efficacy of mesenchymal stem cell therapy.

Michalis Mastri¹, Huey Lin¹, Techung Lee¹.

Abstract

Mesenchymal stem cell (MSC) therapy is entering a challenging phase after completion of many preclinical and clinical trials. Among the major hurdles encountered in MSC therapy are inconsistent stem cell potency, poor cell engraftment and survival, and age/disease-related host tissue impairment. The recognition that MSCs primarily mediate therapeutic benefits through paracrine mechanisms independent of cell differentiation provides a promising framework for enhancing stem cell potency and therapeutic benefits. Several MSC priming approaches are highlighted, which will likely allow us to harness the full potential of adult stem cells for their future routine clinical use.

Keywords: Clinical trial; Mesenchymal stem cell; Paracrine; Therapy

Year: 2014 PMID： 24772236 PMCID： PMC3999784 DOI： 10.4252/wjsc.v6.i2.82

Source DB: PubMed Journal: World J Stem Cells ISSN： 1948-0210 Impact factor: 5.326

126 in total

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Review 4. Biological mechanisms of physical activity in preventing cognitive decline.

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9. HGF/SF is present in normal adult skeletal muscle and is capable of activating satellite cells.

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Enhancing the efficacy of mesenchymal stem cell therapy.

2. Intramuscular VEGF activates an SDF1-dependent progenitor cell cascade and an SDF1-independent muscle paracrine cascade for cardiac repair.

3. Assessment of a nuclear affinity labeling method for tracking implanted mesenchymal stem cells.

Review 4. Biological mechanisms of physical activity in preventing cognitive decline.

5. Genzyme backs Osiris, despite Prochymal flop.

Review 6. The role of plerixafor in optimizing peripheral blood stem cell mobilization for autologous stem cell transplantation.

7. Phenotypic changes of adult porcine mesenchymal stem cells induced by prolonged passaging in culture.

8. Hepatocyte growth factor prevents tissue fibrosis, remodeling, and dysfunction in cardiomyopathic hamster hearts.

9. HGF/SF is present in normal adult skeletal muscle and is capable of activating satellite cells.

10. Mesenchymal stem cells modified with stromal cell-derived factor 1 alpha improve cardiac remodeling via paracrine activation of hepatocyte growth factor in a rat model of myocardial infarction.

1. Mesenchymal stromal cell injection promotes vocal fold scar repair without long-term engraftment.

Review 2. Vibration stimuli and the differentiation of musculoskeletal progenitor cells: Review of results in vitro and in vivo.

3. Freeze-dried rat bone marrow mesenchymal stem cell paracrine factors: a simplified novel material for skin wound therapy.

4. Elimination of allogeneic multipotent stromal cells by host macrophages in different models of regeneration.

Review 5. Kallikrein-kinin in stem cell therapy.

Review 6. Renal stem cell reprogramming: Prospects in regenerative medicine.

Review 7. The Clinical Applications of Endometrial Mesenchymal Stem Cells.

8. Assessment of Enrichment of Human Mesenchymal Stem Cells Based on Plasma and Mitochondrial Membrane Potentials.

Review 9. Allogenic banking of dental pulp stem cells for innovative therapeutics.

10. DNMT3B Is an Oxygen-Sensitive De Novo Methylase in Human Mesenchymal Stem Cells.