PURPOSE OF REVIEW: Cardiovascular diseases are the leading cause of morbidity/mortality in the world. Despite significant progress in cardiovascular medicine, mortality rates have remained steady during the past decade. Therefore, investigators are evaluating novel methods to repair/regenerate the damaged heart. RECENT FINDINGS: Within the past decade, stem cell therapy strategies have been evaluated for the treatment of cardiovascular diseases. Among all postnatal stem cell compartments, bone marrow has been most extensively studied. Recent studies using bone marrow stem cells have suggested that this approach may have beneficial effects on cardiac function, probably by enhancing new cell formation from endogenous cardiac and endothelial stem/progenitor cells. SUMMARY: The present review critically assesses the possible beneficial effects of bone-marrow-derived cell therapy in cardiac ischemia, demonstrating benefits through as yet incompletely understood mechanisms.
PURPOSE OF REVIEW: Cardiovascular diseases are the leading cause of morbidity/mortality in the world. Despite significant progress in cardiovascular medicine, mortality rates have remained steady during the past decade. Therefore, investigators are evaluating novel methods to repair/regenerate the damaged heart. RECENT FINDINGS: Within the past decade, stem cell therapy strategies have been evaluated for the treatment of cardiovascular diseases. Among all postnatal stem cell compartments, bone marrow has been most extensively studied. Recent studies using bone marrow stem cells have suggested that this approach may have beneficial effects on cardiac function, probably by enhancing new cell formation from endogenous cardiac and endothelial stem/progenitor cells. SUMMARY: The present review critically assesses the possible beneficial effects of bone-marrow-derived cell therapy in cardiac ischemia, demonstrating benefits through as yet incompletely understood mechanisms.
Authors: Atta Behfar; Satsuki Yamada; Ruben Crespo-Diaz; Jonathan J Nesbitt; Lois A Rowe; Carmen Perez-Terzic; Vinciane Gaussin; Christian Homsy; Jozef Bartunek; Andre Terzic Journal: J Am Coll Cardiol Date: 2010-08-24 Impact factor: 24.094
Authors: L M Popescu; C G Manole; M Gherghiceanu; A Ardelean; M I Nicolescu; M E Hinescu; S Kostin Journal: J Cell Mol Med Date: 2010-07-13 Impact factor: 5.310
Authors: L M Popescu; Mihaela Gherghiceanu; C G Manole; Maria Simonetta Faussone-Pellegrini Journal: J Cell Mol Med Date: 2009-04-20 Impact factor: 5.310
Authors: Naoki Tajiri; Sandra Acosta; Loren E Glover; Paula C Bickford; Alejandra Jacotte Simancas; Takao Yasuhara; Isao Date; Marianna A Solomita; Ivana Antonucci; Liborio Stuppia; Yuji Kaneko; Cesar V Borlongan Journal: PLoS One Date: 2012-08-17 Impact factor: 3.240
Authors: Naoki Tajiri; Sandra Acosta; Gabriel S Portillo-Gonzales; Daniela Aguirre; Stephanny Reyes; Diego Lozano; Mibel Pabon; Ike Dela Peña; Xunming Ji; Takao Yasuhara; Isao Date; Marianna A Solomita; Ivana Antonucci; Liborio Stuppia; Yuji Kaneko; Cesar V Borlongan Journal: Front Cell Neurosci Date: 2014-08-13 Impact factor: 5.505