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Literature DB >> 18660531

Incorporation of Y'-Ty1 cDNA destabilizes telomeres in Saccharomyces cerevisiae telomerase-negative mutants.

Abstract

Ty1 retrotransposons in Saccharomyces cerevisiae are activated by telomere erosion. Ty1-dependent reverse transcription of mRNA from subtelomeric Y' repeats generates chimeric Y'-Ty1 cDNA. Here, we show that Y'-Ty1 cDNA is incorporated at eroding telomeres in the absence of telomerase. Telomeric incorporation of Y'-Ty1 cDNA promotes genome rearrangements.

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Year: 2008 PMID： 18660531 PMCID： PMC2516100 DOI： 10.1534/genetics.108.089052

Source DB: PubMed Journal: Genetics ISSN： 0016-6731 Impact factor: 4.562

13 in total

1. Telomerase-independent lengthening of yeast telomeres occurs by an abrupt Rad50p-dependent, Rif-inhibited recombinational process.

Authors: S C Teng; J Chang; B McCowan; V A Zakian
Journal: Mol Cell Date: 2000-10 Impact factor: 17.970

2. Ty1 mobilizes subtelomeric Y' elements in telomerase-negative Saccharomyces cerevisiae survivors.

Authors: Patrick H Maxwell; Candice Coombes; Alison E Kenny; Joseph F Lawler; Jef D Boeke; M Joan Curcio
Journal: Mol Cell Biol Date: 2004-11 Impact factor: 4.272

3. Two survivor pathways that allow growth in the absence of telomerase are generated by distinct telomere recombination events.

Authors: Q Chen; A Ijpma; C W Greider
Journal: Mol Cell Biol Date: 2001-03 Impact factor: 4.272

Incorporation of Y'-Ty1 cDNA destabilizes telomeres in Saccharomyces cerevisiae telomerase-negative mutants.

1. Telomerase-independent lengthening of yeast telomeres occurs by an abrupt Rad50p-dependent, Rif-inhibited recombinational process.

2. Ty1 mobilizes subtelomeric Y' elements in telomerase-negative Saccharomyces cerevisiae survivors.

3. Two survivor pathways that allow growth in the absence of telomerase are generated by distinct telomere recombination events.

4. Telomere-telomere recombination is an efficient bypass pathway for telomere maintenance in Saccharomyces cerevisiae.

Review 5. Structure, function, and replication of Saccharomyces cerevisiae telomeres.

6. Activation of a LTR-retrotransposon by telomere erosion.

7. Retrosequence formation restructures the yeast genome.

8. An alternative pathway for yeast telomere maintenance rescues est1- senescence.

9. Recovery of a function involving gene duplication by retroposition in Saccharomyces cerevisiae.

Review 10. Telomeres, chromosome instability and cancer.

Review 1. Border collies of the genome: domestication of an autonomous retrovirus-like transposon.

2. The Ty1 LTR-retrotransposon of budding yeast, Saccharomyces cerevisiae.

3. Reliance of Host-Encoded Regulators of Retromobility on Ty1 Promoter Activity or Architecture.

4. Multiple Mechanisms Contribute To Telomere Maintenance.

5. Structure-Function Model for Kissing Loop Interactions That Initiate Dimerization of Ty1 RNA.