Literature DB >> 1866025

Serotonin uptake in the blood platelets of Alzheimer's disease patients.

R C Arora1, O B Emery, H Y Meltzer.   

Abstract

We determined serotonin (5-HT) uptake in the blood platelets of Alzheimer's disease (AD) patients and comparable age-matched normal controls. The maximum number of 5-HT uptake sites (Vmax) was significantly increased in mild and moderate AD patients, and a trend toward decreased V max was observed in severe AD patients as compared with normal controls. The Km of 5-HT uptake was negatively correlated with the Face-Hand Test (FHT) score of severely ill AD patients, whereas Vmax was correlated with the FHT score and the Mental Status Questionnaire score in the entire AD sample.

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Year:  1991        PMID： 1866025     DOI： 10.1212/wnl.41.8.1307

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  7 in total

1.  Platelet MAO-B activity and serotonin content in patients with dementia: effect of age, medication, and disease.

Authors:  Z Mészáros; D Borcsiczky; M Máté; J Tarcali; T Szombathy; K Tekes; K Magyar
Journal:  Neurochem Res       Date:  1998-06       Impact factor: 3.996

2.  Alzheimer disease: are we intervening too late? Pro.

Authors:  Virginia Olga B Emery
Journal:  J Neural Transm (Vienna)       Date:  2011-06-07       Impact factor: 3.575

3.  Platelet dysfunction in hypercholesterolemia mice, two Alzheimer's disease mouse models and in human patients with Alzheimer's disease.

Authors:  Barbara Plagg; Josef Marksteiner; Kathrin M Kniewallner; Christian Humpel
Journal:  Biogerontology       Date:  2015-05-07       Impact factor: 4.277

4.  Neuroinflammation and amyloid-beta 40 are associated with reduced serotonin transporter (SERT) activity in a transgenic model of familial Alzheimer's disease.

Authors:  Athanasios Metaxas; Marco Anzalone; Ramanan Vaitheeswaran; Sussanne Petersen; Anne M Landau; Bente Finsen
Journal:  Alzheimers Res Ther       Date:  2019-05-01       Impact factor: 6.982

Review 5.  Beyond Haemostasis and Thrombosis: Platelets in Depression and Its Co-Morbidities.

Authors:  Benedetta Izzi; Alfonsina Tirozzi; Chiara Cerletti; Maria Benedetta Donati; Giovanni de Gaetano; Marc F Hoylaerts; Licia Iacoviello; Alessandro Gialluisi
Journal:  Int J Mol Sci       Date:  2020-11-21       Impact factor: 5.923

6.  Alzheimer disease and platelets: how's that relevant.

Authors:  Silvia Catricala; Mauro Torti; Giovanni Ricevuti
Journal:  Immun Ageing       Date:  2012-09-17       Impact factor: 6.400

Review 7.  Platelets, a reliable source for peripheral Alzheimer's disease biomarkers?

Authors:  Michael Veitinger; Balazs Varga; Sheila B Guterres; Maria Zellner
Journal:  Acta Neuropathol Commun       Date:  2014-06-16       Impact factor: 7.801
  7 in total

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