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Literature DB >> 1865880

CDC7 protein kinase activity is required for mitosis and meiosis in Saccharomyces cerevisiae.

Abstract

The product of the CDC7 gene of Saccharomyces cerevisiae has multiple cellular functions, being needed for the initiation of DNA synthesis during mitosis as well as for synaptonemal complex formation and commitment to recombination during meiosis. The CDC7 protein has protein kinase activity and contains the conserved residues characteristic of the protein kinase catalytic domain. To determine which of the cellular functions of CDC7 require this protein kinase activity, we have mutated some of the conserved residues within the CDC7 catalytic domain and have examined the ability of the mutant proteins to support mitosis and meiosis. The results indicate that the protein kinase activity of the CDC7 gene product is essential for its function in both mitosis and meiosis and that this activity is potentially regulated by phosphorylation of the CDC7 protein.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1991 PMID： 1865880 DOI： 10.1007/bf00273937

Source DB: PubMed Journal: Mol Gen Genet ISSN： 0026-8925

32 in total

1. Incompatibility and transforming efficiency of ColE1 and related plasmids.

Authors: G Warren; D Sherratt
Journal: Mol Gen Genet Date: 1978-04-25

2. Sequential gene function in the initiation of Saccharomyces cerevisiae DNA synthesis.

Authors: L M Hereford; L H Hartwell
Journal: J Mol Biol Date: 1974-04-15 Impact factor: 5.469

3. A simple method for the preparation of large quantities of pure plasmid DNA.

Authors: G O Humphreys; G A Willshaw; E S Anderson
Journal: Biochim Biophys Acta Date: 1975-04-02

4. A Saccharomyces cerevisiae genomic plasmid bank based on a centromere-containing shuttle vector.

Authors: M D Rose; P Novick; J H Thomas; D Botstein; G R Fink
Journal: Gene Date: 1987 Impact factor: 3.688

5. Site-specific mutagenesis of cdc2+, a cell cycle control gene of the fission yeast Schizosaccharomyces pombe.

Authors: R Booher; D Beach
Journal: Mol Cell Biol Date: 1986-10 Impact factor: 4.272

6. Molecular characterization of cell cycle gene CDC7 from Saccharomyces cerevisiae.

Authors: M Patterson; R A Sclafani; W L Fangman; J Rosamond
Journal: Mol Cell Biol Date: 1986-05 Impact factor: 4.272

7. Differential regulation of the yeast CDC7 gene during mitosis and meiosis.

Authors: R A Sclafani; M Patterson; J Rosamond; W L Fangman
Journal: Mol Cell Biol Date: 1988-01 Impact factor: 4.272

8. Are mitotic functions required in meiosis?

Authors: G Simchen
Journal: Genetics Date: 1974-04 Impact factor: 4.562

9. A lysine in the ATP-binding site of P130gag-fps is essential for protein-tyrosine kinase activity.

Authors: G Weinmaster; M J Zoller; T Pawson
Journal: EMBO J Date: 1986-01 Impact factor: 11.598

10. Differential phosphorylation of vertebrate p34cdc2 kinase at the G1/S and G2/M transitions of the cell cycle: identification of major phosphorylation sites.

Authors: W Krek; E A Nigg
Journal: EMBO J Date: 1991-02 Impact factor: 11.598

15 in total

1. Cell cycle control of Cdc7p kinase activity through regulation of Dbf4p stability.

Authors: G Oshiro; J C Owens; Y Shellman; R A Sclafani; J J Li
Journal: Mol Cell Biol Date: 1999-07 Impact factor: 4.272

2. Novel fission yeast Cdc7-Dbf4-like kinase complex required for the initiation and progression of meiotic second division.

Authors: Taro Nakamura; Michiko Nakamura-Kubo; Tomohiro Nakamura; Chikashi Shimoda
Journal: Mol Cell Biol Date: 2002-01 Impact factor: 4.272

CDC7 protein kinase activity is required for mitosis and meiosis in Saccharomyces cerevisiae.

1. Incompatibility and transforming efficiency of ColE1 and related plasmids.

2. Sequential gene function in the initiation of Saccharomyces cerevisiae DNA synthesis.

3. A simple method for the preparation of large quantities of pure plasmid DNA.

4. A Saccharomyces cerevisiae genomic plasmid bank based on a centromere-containing shuttle vector.

5. Site-specific mutagenesis of cdc2+, a cell cycle control gene of the fission yeast Schizosaccharomyces pombe.

6. Molecular characterization of cell cycle gene CDC7 from Saccharomyces cerevisiae.

7. Differential regulation of the yeast CDC7 gene during mitosis and meiosis.

8. Are mitotic functions required in meiosis?

9. A lysine in the ATP-binding site of P130gag-fps is essential for protein-tyrosine kinase activity.

10. Differential phosphorylation of vertebrate p34cdc2 kinase at the G1/S and G2/M transitions of the cell cycle: identification of major phosphorylation sites.

1. Cell cycle control of Cdc7p kinase activity through regulation of Dbf4p stability.

2. Novel fission yeast Cdc7-Dbf4-like kinase complex required for the initiation and progression of meiotic second division.

Review 3. Cell cycle regulation in Aspergillus by two protein kinases.

4. Inactivation of Cdc7 kinase in mouse ES cells results in S-phase arrest and p53-dependent cell death.

5. The Cdc7 protein kinase is required for origin firing during S phase.

6. RAD53 regulates DBF4 independently of checkpoint function in Saccharomyces cerevisiae.

7. Cell cycle regulation of the yeast Cdc7 protein kinase by association with the Dbf4 protein.

8. Molecular genetic studies of the Cdc7 protein kinase and induced mutagenesis in yeast.

9. Regulation of Saccharomyces cerevisiae CDC7 function during the cell cycle.

10. Characterization of the mus308 gene in Drosophila melanogaster.