Literature DB >> 18658045

Integrins: the keys to unlocking angiogenesis.

Rita Silva1, Gabriela D'Amico, Kairbaan M Hodivala-Dilke, Louise E Reynolds.   

Abstract

Angiogenesis, the formation of new blood vessels from preexisting vasculature, contributes to the pathogenesis of many disorders, including ischemic diseases and cancer. Integrins are cell adhesion molecules that are expressed on the surface of endothelial cells and pericytes, making them potential targets for antiangiogenic therapy. Here we review the contribution of endothelial and mural cell integrins to angiogenesis and highlight their potential as antiangiogenesis targets.

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Year:  2008        PMID： 18658045     DOI： 10.1161/ATVBAHA.108.172015

Source DB:  PubMed          Journal:  Arterioscler Thromb Vasc Biol        ISSN： 1079-5642            Impact factor:   8.311


  114 in total

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Authors:  Joseph W Franses; Elazer R Edelman
Journal:  Cancer Res       Date:  2011-12-05       Impact factor: 12.701

2.  Brain pericytes: emerging concepts and functional roles in brain homeostasis.

Authors:  Masahiro Kamouchi; Tetsuro Ago; Takanari Kitazono
Journal:  Cell Mol Neurobiol       Date:  2011-03       Impact factor: 5.046

Review 3.  Integrins as therapeutic targets: lessons and opportunities.

Authors:  Dermot Cox; Marian Brennan; Niamh Moran
Journal:  Nat Rev Drug Discov       Date:  2010-10       Impact factor: 84.694

4.  An angiogenic role for the α5β1 integrin in promoting endothelial cell proliferation during cerebral hypoxia.

Authors:  Longxuan Li; Jennifer Welser-Alves; Arjan van der Flier; Amin Boroujerdi; Richard O Hynes; Richard Milner
Journal:  Exp Neurol       Date:  2012-06-18       Impact factor: 5.330

5.  Beyond the Knudson's hypothesis in von Hippel-Lindau (VHL) disease-proposing vitronectin as a "gene modifier".

Authors:  Francesco Turturro
Journal:  J Mol Med (Berl)       Date:  2009-06       Impact factor: 4.599

6.  Sprouty4 regulates endothelial cell migration via modulating integrin β3 stability through c-Src.

Authors:  Yan Gong; Xuehui Yang; Qing He; Lindsey Gower; Igor Prudovsky; Calvin P H Vary; Peter C Brooks; Robert E Friesel
Journal:  Angiogenesis       Date:  2013-08-17       Impact factor: 9.596

7.  Absence of the alpha v beta 3 integrin dictates the time-course of angiogenesis in the hypoxic central nervous system: accelerated endothelial proliferation correlates with compensatory increases in alpha 5 beta 1 integrin expression.

Authors:  Longxuan Li; Jennifer V Welser; Richard Milner
Journal:  J Cereb Blood Flow Metab       Date:  2010-01-20       Impact factor: 6.200

Review 8.  Effects of integrins and integrin αvβ3 inhibitor on angiogenesis in cerebral ischemic stroke.

Authors:  Jia-Jia Bi; Li Yi
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2014-06-18

9.  Intracellular Pathways Involved in Bone Regeneration Triggered by Recombinant Silk-silica Chimeras.

Authors:  Zaira Martín-Moldes; Davoud Ebrahimi; Robyn Plowright; Nina Dinjaski; Carole C Perry; Markus J Buehler; David L Kaplan
Journal:  Adv Funct Mater       Date:  2017-09-04       Impact factor: 18.808

10.  Genome expression profiling and network analysis of nitrite therapy during chronic ischemia: possible mechanisms and interesting molecules.

Authors:  Christopher B Pattillo; Kai Fang; Sibile Pardue; Christopher G Kevil
Journal:  Nitric Oxide       Date:  2009-12-04       Impact factor: 4.427
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