Literature DB >> 24939290

Effects of integrins and integrin αvβ3 inhibitor on angiogenesis in cerebral ischemic stroke.

Jia-Jia Bi1, Li Yi2.   

Abstract

Integrins such as αvβ3, α5β1 play a key role in angiogenesis regulation, invasion and metastasis, inflammation, wound healing, etc. The up-regulation of integrin αvβ3 after cerebral ischemic stroke can promote angiogenesis, which in turn improves functional recovery. In addition, the integrin αvβ3 inhibitor can block the blood-brain barrier (BBB) leakage induced by vascular endothelial growth factor (VEGF) and also can reduce inflammatory reaction, decrease the deposition of fibrinogen. Other studies showed that integrin αvβ3 is not essential in revascularization. Therefore, the effect of integrin αvβ3 in the whole process of brain function recovery merits further study.

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Year:  2014        PMID： 24939290     DOI： 10.1007/s11596-014-1274-4

Source DB:  PubMed          Journal:  J Huazhong Univ Sci Technolog Med Sci        ISSN： 1672-0733


  76 in total

1.  Cerebral ischemia, matrix metalloproteinases, and TNF-alpha: MMP inhibitors may act not exclusively by reducing MMP activity.

Authors:  Michael Dittmar; Georgios Kiourkenidis; Markus Horn; Susanne Bollwein; Günther Bernhardt
Journal:  Stroke       Date:  2004-06-10       Impact factor: 7.914

2.  Imaging of integrin α(V)β(3) expression using (68)Ga-RGD positron emission tomography in pediatric cerebral infarct.

Authors:  Hongyoon Choi; Ji Hoon Phi; Jin Chul Paeng; Seung-Ki Kim; Yun-Sang Lee; Jae Min Jeong; June-Key Chung; Dong Soo Lee; Kyu-Chang Wang
Journal:  Mol Imaging       Date:  2013-06       Impact factor: 4.488

3.  Synthesis, in vitro, and in vivo characterization of an integrin alpha(v)beta(3)-targeted molecular probe for optical imaging of tumor.

Authors:  Christopher A Burnett; Jianwu Xie; Jade Quijano; Zhimin Shen; Finie Hunter; Monica Bur; King C P Li; S Narasimhan Danthi
Journal:  Bioorg Med Chem       Date:  2005-06-01       Impact factor: 3.641

4.  Collateral growth and angiogenesis around cortical stroke.

Authors:  L Wei; J P Erinjeri; C M Rovainen; T A Woolsey
Journal:  Stroke       Date:  2001-09       Impact factor: 7.914

5.  Increased expression of fibronectin and the alpha 5 beta 1 integrin in angiogenic cerebral blood vessels of mice subject to hypobaric hypoxia.

Authors:  Richard Milner; Stephanie Hung; Bernadette Erokwu; Paula Dore-Duffy; Joseph C LaManna; Gregory J del Zoppo
Journal:  Mol Cell Neurosci       Date:  2008-02-13       Impact factor: 4.314

6.  Inhibition of inflammatory lymphangiogenesis by integrin alpha5 blockade.

Authors:  Tina Dietrich; Jasmine Onderka; Felix Bock; Friedrich E Kruse; Dörte Vossmeyer; Roland Stragies; Grit Zahn; Claus Cursiefen
Journal:  Am J Pathol       Date:  2007-07       Impact factor: 4.307

7.  Evaluation of alphavbeta3 integrin-targeted positron emission tomography tracer 18F-galacto-RGD for imaging of vascular inflammation in atherosclerotic mice.

Authors:  Iina Laitinen; Antti Saraste; Eliane Weidl; Thorsten Poethko; Axel W Weber; Stephan G Nekolla; Pia Leppänen; Seppo Ylä-Herttuala; Gabriele Hölzlwimmer; Axel Walch; Irene Esposito; Hans-Jürgen Wester; Juhani Knuuti; Markus Schwaiger
Journal:  Circ Cardiovasc Imaging       Date:  2009-05-13       Impact factor: 7.792

8.  Integrin beta4 signaling promotes tumor angiogenesis.

Authors:  Sotiris N Nikolopoulos; Pamela Blaikie; Toshiaki Yoshioka; Wenjun Guo; Filippo G Giancotti
Journal:  Cancer Cell       Date:  2004-11       Impact factor: 31.743

9.  Role of angiogenesis in patients with cerebral ischemic stroke.

Authors:  J Krupinski; J Kaluza; P Kumar; S Kumar; J M Wang
Journal:  Stroke       Date:  1994-09       Impact factor: 7.914

10.  A role for the alphavbeta3 integrin in the transmigration of monocytes.

Authors:  D Weerasinghe; K P McHugh; F P Ross; E J Brown; R H Gisler; B A Imhof
Journal:  J Cell Biol       Date:  1998-07-27       Impact factor: 10.539
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  4 in total

Review 1.  Neuroprotective potential of cerium oxide nanoparticles for focal cerebral ischemic stroke.

Authors:  Da Zhou; Ting Fang; Lin-Qing Lu; Li Yi
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2016-07-28

Review 2.  The uPAR System as a Potential Therapeutic Target in the Diseased Eye.

Authors:  Maurizio Cammalleri; Massimo Dal Monte; Vincenzo Pavone; Mario De Rosa; Dario Rusciano; Paola Bagnoli
Journal:  Cells       Date:  2019-08-18       Impact factor: 6.600

3.  The urokinase-type plasminogen activator system as drug target in retinitis pigmentosa: New pre-clinical evidence in the rd10 mouse model.

Authors:  Maurizio Cammalleri; Massimo Dal Monte; Filippo Locri; Valeria Pecci; Mario De Rosa; Vincenzo Pavone; Paola Bagnoli
Journal:  J Cell Mol Med       Date:  2019-06-28       Impact factor: 5.310

4.  Transcriptional Response and Morphological Features of the Neurovascular Unit and Associated Extracellular Matrix After Experimental Stroke in Mice.

Authors:  Susanne Aleithe; Alexandra Blietz; Bianca Mages; Constance Hobusch; Wolfgang Härtig; Dominik Michalski
Journal:  Mol Neurobiol       Date:  2019-05-14       Impact factor: 5.590
  4 in total

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