| Literature DB >> 1865332 |
H Tatematsu1, M Mori, T H Yang, J J Chang, T T Lee, K H Lee.
Abstract
Virosecurinine (1) and viroallosecurinine (2) were isolated as two cytotoxic alkaloids from the leaves of Securinega virosa. A comparison of the cytotoxicity of 1 and several of its derivatives indicates that an alpha,beta- and a gamma,delta-unsaturated lactone located in a strained ring system, such as rings -B, -C, and -D of 1, is structurally required for significant cytotoxicity.Entities:
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Year: 1991 PMID： 1865332 DOI： 10.1002/jps.2600800408
Source DB: PubMed Journal: J Pharm Sci ISSN： 0022-3549 Impact factor: 3.534