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Literature DB >> 18653244

Ingress of blood-borne macrophages across the blood-brain barrier in murine HIV-1 encephalitis.

Yutong Liu¹, Mariano G Uberti, Huanyu Dou, Rebecca Banerjee, Cassi B Grotepas, David K Stone, Barrett E Rabinow, Howard E Gendelman, Michael D Boska.

Abstract

Blood-borne macrophage ingress into brain in HIV-1 associated neurocognitive disorders governs the tempo of disease. We used superparamagnetic iron-oxide particles loaded into murine bone marrow-derived macrophages (BMM) injected intravenously into HIV-1 encephalitis mice to quantitatively assess BMM entry into diseased brain regions. Magnetic resonance imaging tests were validated by histological coregistration and enhanced image processing. The demonstration of robust BMM migration into areas of focal encephalitis provide 'proof of concept' for the use of MRI to monitor macrophage ingress into brain.

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Year: 2008 PMID： 18653244 PMCID： PMC2572762 DOI： 10.1016/j.jneuroim.2008.06.009

Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478

61 in total

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Review 10. Advances in neuroimaging for HIV-1 associated neurological dysfunction: clues to the diagnosis, pathogenesis and therapeutic monitoring.

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9 in total

Ingress of blood-borne macrophages across the blood-brain barrier in murine HIV-1 encephalitis.

1. Caught in the act: in vivo mapping of macrophage infiltration in nerve injury by magnetic resonance imaging.

2. Development of a macrophage-based nanoparticle platform for antiretroviral drug delivery.

3. A methodology for registration of a histological slide and in vivo MRI volume based on optimizing mutual information.

4. Interindividual functional mapping: a nonlinear local approach.

Review 5. Image processing in stereotactic planning: volume visualization and image registration.

6. Demonstration of accuracy and clinical versatility of mutual information for automatic multimodality image fusion using affine and thin-plate spline warped geometric deformations.

7. Human immunodeficiency virus encephalitis in SCID mice.

8. Shape and size of the corpus callosum in schizophrenia and schizotypal personality disorder.

9. A meta-algorithm for brain extraction in MRI.

Review 10. Advances in neuroimaging for HIV-1 associated neurological dysfunction: clues to the diagnosis, pathogenesis and therapeutic monitoring.

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