OBJECTIVES: Following the recent novel finding from genomewide association studies that sequence variation on chromosome 9p21 is a genetic factor for coronary artery disease, we investigated whether the genetic variant influenced the development of atherosclerosis and its progression in a population-based, prospective study. BACKGROUND: Recently, several genomewide association studies revealed a highly significant association between variation on chromosome 9p21 and risk of coronary artery disease. METHODS: We studied the rs1333049 polymorphism located on chromosome 9p21 in a cohort of 769 individuals who participated in the Bruneck study with long-term follow-up data on carotid atherosclerosis measured by high-resolution duplex ultrasound and incident cardiovascular disease. RESULTS: The C allele was associated not only with prevalent carotid atherosclerosis (odds ratio [OR]: 1.46 [95% confidence interval (CI): 1.13 to 1.88]; OR: 1.43 [95% CI: 1.11 to 1.84]; and OR: 1.44 [95% CI: 1.11 to 1.87] for each copy of C allele, calculated from data collected in 1990, 1995, and 2000, respectively), but also with progression of atherosclerosis (OR: 1.73 [95% CI: 1.36 to 2.21] during 1990 to 1995, and OR: 1.87 [95% CI: 1.44 to 2.42] during 1995 to 2000). In addition, the C allele was related to incident cardiovascular disease (hazard ratio: 1.37 [95% CI: 1.05 to 1.79]). There was evidence of an interaction between genotype and abdominal obesity on atherosclerosis and cardiovascular risk. CONCLUSIONS: The results of this population-based, prospective study indicate that the sequence variation on chromosome 9p21 influences atherosclerosis development and progression.
OBJECTIVES: Following the recent novel finding from genomewide association studies that sequence variation on chromosome 9p21 is a genetic factor for coronary artery disease, we investigated whether the genetic variant influenced the development of atherosclerosis and its progression in a population-based, prospective study. BACKGROUND: Recently, several genomewide association studies revealed a highly significant association between variation on chromosome 9p21 and risk of coronary artery disease. METHODS: We studied the rs1333049 polymorphism located on chromosome 9p21 in a cohort of 769 individuals who participated in the Bruneck study with long-term follow-up data on carotid atherosclerosis measured by high-resolution duplex ultrasound and incident cardiovascular disease. RESULTS: The C allele was associated not only with prevalent carotid atherosclerosis (odds ratio [OR]: 1.46 [95% confidence interval (CI): 1.13 to 1.88]; OR: 1.43 [95% CI: 1.11 to 1.84]; and OR: 1.44 [95% CI: 1.11 to 1.87] for each copy of C allele, calculated from data collected in 1990, 1995, and 2000, respectively), but also with progression of atherosclerosis (OR: 1.73 [95% CI: 1.36 to 2.21] during 1990 to 1995, and OR: 1.87 [95% CI: 1.44 to 2.42] during 1995 to 2000). In addition, the C allele was related to incident cardiovascular disease (hazard ratio: 1.37 [95% CI: 1.05 to 1.79]). There was evidence of an interaction between genotype and abdominal obesity on atherosclerosis and cardiovascular risk. CONCLUSIONS: The results of this population-based, prospective study indicate that the sequence variation on chromosome 9p21 influences atherosclerosis development and progression.
Authors: Cara L Carty; Petra Buzková; Myriam Fornage; Nora Franceschini; Shelley Cole; Gerardo Heiss; Lucia A Hindorff; Barbara V Howard; Sue Mann; Lisa W Martin; Ying Zhang; Tara C Matise; Ross Prentice; Alexander P Reiner; Charles Kooperberg Journal: Circ Cardiovasc Genet Date: 2012-03-08
Authors: Lili Zhang; Petra Buzkova; Christina L Wassel; Mary J Roman; Kari E North; Dana C Crawford; Jonathan Boston; Kristin D Brown-Gentry; Shelley A Cole; Ewa Deelman; Robert Goodloe; Sarah Wilson; Gerardo Heiss; Nancy S Jenny; Neal W Jorgensen; Tara C Matise; Bob E McClellan; Alejandro Q Nato; Marylyn D Ritchie; Nora Franceschini; W H Linda Kao Journal: Atherosclerosis Date: 2013-03-13 Impact factor: 5.162
Authors: Christopher Newton-Cheh; Nancy R Cook; Martin VanDenburgh; Eric B Rimm; Paul M Ridker; Christine M Albert Journal: Circulation Date: 2009-11-09 Impact factor: 29.690