Literature DB >> 18643743

Pilot trial of N-acetylcysteine and tigecycline as a catheter-lock solution for treatment of hemodialysis catheter-associated bacteremia.

Saima Aslam1, Barbara W Trautner, Venkat Ramanathan, Rabih O Darouiche.   

Abstract

We evaluated a catheter-lock solution consisting of N-acetylcysteine, tigecycline, and heparin for catheter salvage in patients with hemodialysis catheter-associated bacteremia. Eighteen case patients received the catheter-lock solution for 14 days plus systemic antibiotic therapy. Treatment was successful for 15 (83%) of the 18 case patients within 90 days of follow-up, with a median catheter retention interval of 64.5 days.

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Year:  2008        PMID： 18643743     DOI： 10.1086/590192

Source DB:  PubMed          Journal:  Infect Control Hosp Epidemiol        ISSN： 0899-823X            Impact factor:   3.254


  10 in total

1.  Successful tigecycline lock therapy in a Lactobacillus rhamnosus catheter-related bloodstream infection.

Authors:  F Bartalesi; S Veloci; F Baragli; E Mantengoli; S Guidi; A M Bartolesi; R Mannino; P Pecile; A Bartoloni
Journal:  Infection       Date:  2011-10-18       Impact factor: 3.553

Review 2.  Biofilm-related infections: bridging the gap between clinical management and fundamental aspects of recalcitrance toward antibiotics.

Authors:  David Lebeaux; Jean-Marc Ghigo; Christophe Beloin
Journal:  Microbiol Mol Biol Rev       Date:  2014-09       Impact factor: 11.056

Review 3.  Systematic review and meta-analysis on management of hemodialysis catheter-related bacteremia.

Authors:  Saima Aslam; Florin Vaida; Michele Ritter; Ravindra L Mehta
Journal:  J Am Soc Nephrol       Date:  2014-05-22       Impact factor: 10.121

4.  Mechanical integrity of hemodialysis catheters after exposure to a novel catheter lock solution.

Authors:  Saima Aslam; Rabih O Darouiche
Journal:  Infect Control Hosp Epidemiol       Date:  2010-11       Impact factor: 3.254

5.  Role of antibiofilm-antimicrobial agents in controlling device-related infections.

Authors:  Saima Aslam; Rabih O Darouiche
Journal:  Int J Artif Organs       Date:  2011-09       Impact factor: 1.595

6.  N-acetylcysteine lock solution prevents catheter-associated bacteremia in rabbits.

Authors:  Saima Aslam; Keith Jenne; Sharon Reed; Mahmoud Ghannoum; Ravindra Mehta; Rabih Darouiche
Journal:  Int J Artif Organs       Date:  2012-10       Impact factor: 1.595

Review 7.  Anticoagulants and antiplatelet agents for preventing central venous haemodialysis catheter malfunction in patients with end-stage kidney disease.

Authors:  Ying Wang; Jessica N Ivany; Vlado Perkovic; Martin P Gallagher; Mark Woodward; Meg J Jardine
Journal:  Cochrane Database Syst Rev       Date:  2016-04-04

Review 8.  Antibiotic lock therapy: review of technique and logistical challenges.

Authors:  Julie Ann Justo; P Brandon Bookstaver
Journal:  Infect Drug Resist       Date:  2014-12-12       Impact factor: 4.003

9.  Protective Effect of N-Acetyl-Cysteine (NAC) in Lipopolysaccharide (LPS)-Associated Inflammatory Response in Rat Neonates.

Authors:  Nizar Khatib; Zeev Weiner; Yuval Ginsberg; Nibal Awad; Ron Beloosesky
Journal:  Rambam Maimonides Med J       Date:  2017-04-28

10.  Association of different Candida species with catheter-related candidemia, and the potential antifungal treatments against their adhesion properties and biofilm-forming capabilities.

Authors:  Xiao-Shu Zuo; Yanan Liu; Xuan Cai; Liying Zhan; Ke Hu
Journal:  J Clin Lab Anal       Date:  2021-02-19       Impact factor: 2.352
  10 in total

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