| Literature DB >> 18642069 |
Aisling Mulligan1, Richard J L Anney, Myra O'Regan, Wai Chen, Louise Butler, Michael Fitzgerald, Jan Buitelaar, Hans-Christoph Steinhausen, Aribert Rothenberger, Ruud Minderaa, Judith Nijmeijer, Pieter J Hoekstra, Robert D Oades, Herbert Roeyers, Cathelijne Buschgens, Hanna Christiansen, Barbara Franke, Isabel Gabriels, Catharina Hartman, Jonna Kuntsi, Rafaela Marco, Sheera Meidad, Ueli Mueller, Lamprini Psychogiou, Nanda Rommelse, Margaret Thompson, Henrik Uebel, Tobias Banaschewski, Richard Ebstein, Jacques Eisenberg, Iris Manor, Ana Miranda, Fernando Mulas, Joseph Sergeant, Edmund Sonuga-Barke, Phil Asherson, Stephen V Faraone, Michael Gill.
Abstract
It is hypothesised that autism symptoms are present in Attention-Deficit/Hyperactivity Disorder (ADHD), are familial and index subtypes of ADHD. Autism symptoms were compared in 821 ADHD probands, 1050 siblings and 149 controls. Shared familiality of autism symptoms and ADHD was calculated using DeFries-Fulker analysis. Autism symptoms were higher in probands than siblings or controls, and higher in male siblings than male controls. Autism symptoms were familial, partly shared with familiality of ADHD in males. Latent class analysis using SCQ-score yielded five classes; Class 1(31%) had few autism symptoms and low comorbidity; Classes 2-4 were intermediate; Class 5(7%) had high autism symptoms and comorbidity. Thus autism symptoms in ADHD represent a familial trait associated with increased neurodevelopmental and oppositional/conduct disorders.Entities:
Mesh：
Year: 2008 PMID： 18642069 DOI： 10.1007/s10803-008-0621-3
Source DB: PubMed Journal: J Autism Dev Disord ISSN： 0162-3257