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Literature DB >> 18640136

Insights into the regulation of 5-HT2A serotonin receptors by scaffolding proteins and kinases.

John A Allen¹, Prem N Yadav, Bryan L Roth.

Abstract

5-HT(2A) serotonin receptors are essential molecular targets for the actions of LSD-like hallucinogens and atypical antipsychotic drugs. 5-HT(2A) serotonin receptors also mediate a variety of physiological processes in peripheral and central nervous systems including platelet aggregation, smooth muscle contraction, and the modulation of mood and perception. Scaffolding proteins have emerged as important regulators of 5-HT(2A) receptors and our recent studies suggest multiple scaffolds exist for 5-HT(2A) receptors including PSD95, arrestin, and caveolin. In addition, a novel interaction has emerged between p90 ribosomal S6 kinase and 5-HT(2A) receptors which attenuates receptor signaling. This article reviews our recent studies and emphasizes the role of scaffolding proteins and kinases in the regulation of 5-HT(2A) trafficking, targeting and signaling.

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Year: 2008 PMID： 18640136 PMCID： PMC2629388 DOI： 10.1016/j.neuropharm.2008.06.048

Source DB: PubMed Journal: Neuropharmacology ISSN： 0028-3908 Impact factor: 5.250

90 in total

Review 1. G-protein-coupled receptors at a glance.

Authors: Wesley K Kroeze; Douglas J Sheffler; Bryan L Roth
Journal: J Cell Sci Date: 2003-12-15 Impact factor: 5.285

2. Similar ultrastructural distribution of the 5-HT(2A) serotonin receptor and microtubule-associated protein MAP1A in cortical dendrites of adult rat.

Authors: V Cornea-Hébert; K C Watkins; B L Roth; W K Kroeze; P Gaudreau; N Leclerc; L Descarries
Journal: Neuroscience Date: 2002 Impact factor: 3.590

Review 3. Lipid rafts, detergent-resistant membranes, and raft targeting signals.

Authors: Deborah A Brown
Journal: Physiology (Bethesda) Date: 2006-12

4. p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling.

Authors: Douglas J Sheffler; Wesley K Kroeze; Bonnie G Garcia; Ariel Y Deutch; Sandra J Hufeisen; Patrick Leahy; Jens C Brüning; Bryan L Roth
Journal: Proc Natl Acad Sci U S A Date: 2006-03-10 Impact factor: 11.205

Review 5. The molecular biology of serotonin receptors: therapeutic implications for the interface of mood and psychosis.

Authors: W K Kroeze; B L Roth
Journal: Biol Psychiatry Date: 1998-12-01 Impact factor: 13.382

6. Structure and function of the third intracellular loop of the 5-hydroxytryptamine2A receptor: the third intracellular loop is alpha-helical and binds purified arrestins.

Authors: E I Gelber; W K Kroeze; D L Willins; J A Gray; C A Sinar; E G Hyde; V Gurevich; J Benovic; B L Roth
Journal: J Neurochem Date: 1999-05 Impact factor: 5.372

7. 5-Hydroxytryptamine2A serotonin receptors in the primate cerebral cortex: possible site of action of hallucinogenic and antipsychotic drugs in pyramidal cell apical dendrites.

Authors: R L Jakab; P S Goldman-Rakic
Journal: Proc Natl Acad Sci U S A Date: 1998-01-20 Impact factor: 11.205

8. Regulation of 5-HT2A/C receptors and DOI-induced behaviors by protein kinase Cgamma.

Authors: Barbara J Bowers; Jill Miyamoto-Ditmon; Jeanne M Wehner
Journal: Pharmacol Biochem Behav Date: 2006-11-15 Impact factor: 3.533

Review 9. Pleiotropic behavior of 5-HT2A and 5-HT2C receptor agonists.

Authors: K A Berg; S Maayani; J Goldfarb; W P Clarke
Journal: Ann N Y Acad Sci Date: 1998-12-15 Impact factor: 5.691

Review 10. Molecular targets for treating cognitive dysfunction in schizophrenia.

Authors: John A Gray; Bryan L Roth
Journal: Schizophr Bull Date: 2007-07-07 Impact factor: 7.348

23 in total

1. Disrupting 5-HT(2A) receptor/PDZ protein interactions reduces hyperalgesia and enhances SSRI efficacy in neuropathic pain.

Authors: Xavier Pichon; Anne S Wattiez; Carine Becamel; Ingrid Ehrlich; Joel Bockaert; Alain Eschalier; Philippe Marin; Christine Courteix
Journal: Mol Ther Date: 2010-06-08 Impact factor: 11.454

2. Irving Page Lecture: 5-HT(2A) serotonin receptor biology: interacting proteins, kinases and paradoxical regulation.

Authors: Bryan L Roth
Journal: Neuropharmacology Date: 2011-02-01 Impact factor: 5.250

3. Genetic deletion of p90 ribosomal S6 kinase 2 alters patterns of 5-hydroxytryptamine 2A serotonin receptor functional selectivity.

Authors: Ryan T Strachan; Noah Sciaky; Mark R Cronan; Wesley K Kroeze; Bryan L Roth
Journal: Mol Pharmacol Date: 2009-11-20 Impact factor: 4.436

10. Ribosomal S6 kinase 2 directly phosphorylates the 5-hydroxytryptamine 2A (5-HT2A) serotonin receptor, thereby modulating 5-HT2A signaling.

Authors: Ryan T Strachan; Douglas J Sheffler; Belinda Willard; Michael Kinter; Janna G Kiselar; Bryan L Roth
Journal: J Biol Chem Date: 2008-12-22 Impact factor: 5.157