| Literature DB >> 18637692 |
Marco Santarem1, Corinne Vanucci-Bacqué, Gérard Lhommet.
Abstract
An efficient formal total synthesis of (+)-gephyrotoxin is described. The key step of our strategy relies on the diastereoselective reduction of a chiral pyrrolidine beta-enamino ester obtained by condensation of ( S)-phenylglycinol on a protected 8-hydroxy-3,6-dioxooctanoate.Entities:
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Year: 2008 PMID： 18637692 DOI： 10.1021/jo801150e
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354