BACKGROUND AND PURPOSE: Superficial siderosis of the central nervous system results from chronic bleeding in the superficial layers of the cortex and spinal cord. In cerebral amyloid angiopathy (CAA), there is amyloid deposition in meningeal and meningo-cortical arteries and capillaries, predisposing them to rupture. CAA is frequently associated with Alzheimer disease (AD). METHODS: We report a series of 3 AD patients with MRI evidence of superficial siderosis. Two had neuropathological examination confirming superficial siderosis, AD, and CAA. CONCLUSIONS: Superficial siderosis should be recognized within the spectrum of AD with CAA and considered as a possible antemortem diagnostic feature.
BACKGROUND AND PURPOSE: Superficial siderosis of the central nervous system results from chronic bleeding in the superficial layers of the cortex and spinal cord. In cerebral amyloid angiopathy (CAA), there is amyloid deposition in meningeal and meningo-cortical arteries and capillaries, predisposing them to rupture. CAA is frequently associated with Alzheimer disease (AD). METHODS: We report a series of 3 ADpatients with MRI evidence of superficial siderosis. Two had neuropathological examination confirming superficial siderosis, AD, and CAA. CONCLUSIONS: Superficial siderosis should be recognized within the spectrum of AD with CAA and considered as a possible antemortem diagnostic feature.
Authors: Sara Shams; Juha Martola; Andreas Charidimou; Lena Cavallin; Tobias Granberg; Mana Shams; Yngve Forslin; Peter Aspelin; Maria Kristoffersen-Wiberg; Lars-Olof Wahlund Journal: Neurology Date: 2016-08-17 Impact factor: 9.910
Authors: S Kumar; R P Goddeau; M H Selim; A Thomas; G Schlaug; A Alhazzani; D E Searls; L R Caplan Journal: Neurology Date: 2010-03-16 Impact factor: 9.910