Literature DB >> 18631125

Regulation of the RelA (p65) transactivation domain.

John M O'Shea1, Neil D Perkins.   

Abstract

The RelA (p65) NF-kappaB (nuclear factor kappaB) subunit contains an extremely active C-terminal transcriptional activation domain, required for its cellular function. In the present article, we review our knowledge of this domain, its modifications and its known interacting proteins. Moreover, we discuss how analysis of its evolutionary conservation reveals distinct subdomains and conserved residues that might give insights into its regulation and function.

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Year:  2008        PMID： 18631125     DOI： 10.1042/BST0360603

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   5.407


  30 in total

1.  Physical and functional interaction between the ID1 and p65 for activation of NF-κB.

Authors:  Xiao Peng; Yuna Wang; Swapna Kolli; Junpeng Deng; Li Li; Zhixin Wang; J Usha Raj; Deming Gou
Journal:  Am J Physiol Cell Physiol       Date:  2012-05-16       Impact factor: 4.249

Review 2.  Specification of DNA binding activity of NF-kappaB proteins.

Authors:  Fengyi Wan; Michael J Lenardo
Journal:  Cold Spring Harb Perspect Biol       Date:  2009-10       Impact factor: 10.005

3.  Novel p65 binding glucocorticoid-induced leucine zipper peptide suppresses experimental autoimmune encephalomyelitis.

Authors:  Mythily Srinivasan; Srihari Janardhanam
Journal:  J Biol Chem       Date:  2011-09-29       Impact factor: 5.157

4.  Lysine methylation of promoter-bound transcription factors and relevance to cancer.

Authors:  George R Stark; Yuxin Wang; Tao Lu
Journal:  Cell Res       Date:  2010-12-14       Impact factor: 25.617

5.  Designer monotransregulators provide a basis for a transcriptional therapy for de novo endocrine-resistant breast cancer.

Authors:  Stephanie L Nott; Yanfang Huang; Aja Kalkanoglu; Kathryn Harper; Ming Chen; Scott F Paoni; Bruce M Fenton; Mesut Muyan
Journal:  Mol Med       Date:  2009-11-17       Impact factor: 6.354

Review 6.  The diverse and complex roles of NF-κB subunits in cancer.

Authors:  Neil D Perkins
Journal:  Nat Rev Cancer       Date:  2012-01-19       Impact factor: 60.716

7.  Thr435 phosphorylation regulates RelA (p65) NF-kappaB subunit transactivation.

Authors:  John M O'Shea; Neil D Perkins
Journal:  Biochem J       Date:  2010-02-24       Impact factor: 3.857

8.  Cyclin-dependent kinase 6 phosphorylates NF-κB P65 at serine 536 and contributes to the regulation of inflammatory gene expression.

Authors:  Holger Buss; Katja Handschick; Nadine Jurrmann; Pirita Pekkonen; Knut Beuerlein; Helmut Müller; Robin Wait; Jeremy Saklatvala; Päivi M Ojala; M Lienhard Schmitz; Michael Naumann; Michael Kracht
Journal:  PLoS One       Date:  2012-12-26       Impact factor: 3.240

9.  The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-κB.

Authors:  Elisabeth Ziesché; Daniela Kettner-Buhrow; Axel Weber; Tobias Wittwer; Liane Jurida; Johanna Soelch; Helmut Müller; Doris Newel; Petra Kronich; Heike Schneider; Oliver Dittrich-Breiholz; Srividya Bhaskara; Scott W Hiebert; Michael O Hottiger; Haiying Li; Ezra Burstein; M Lienhard Schmitz; Michael Kracht
Journal:  Nucleic Acids Res       Date:  2012-10-19       Impact factor: 16.971

10.  Overexpression of p65 attenuates celecoxib-induced cell death in MDA-MB-231 human breast cancer cell line.

Authors:  Ling Wang; Fubiao Kang; Jie Li; Jing Zhang; Baoen Shan
Journal:  Cancer Cell Int       Date:  2013-02-12       Impact factor: 5.722
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