Literature DB >> 18630930

The nitrite anion binds to human hemoglobin via the uncommon O-nitrito mode.

Jun Yi1, Martin K Safo, George B Richter-Addo.   

Abstract

The nitrite anion is known to oxidize and degrade hemoglobin (Hb). Recent literature reports suggest a nitrite reductase activity for Hb, converting nitrite into nitric oxide. Surprisingly, no structural information about Hb-nitrite interactions has been reported. We have determined the crystal structure of the ferric Hb-nitrite complex at 1.80 A resolution. The nitrite ligand adopts the uncommon O-nitrito binding mode. In addition, the nitrito conformations in the alpha and beta subunits are different, reflecting subtle effects of the distal His in orienting the nitrite ligand in the O-nitrito binding mode.

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Year:  2008        PMID： 18630930     DOI： 10.1021/bi801015c

Source DB:  PubMed          Journal:  Biochemistry        ISSN： 0006-2960            Impact factor:   3.162


  27 in total

1.  Structure of human R-state aquomethemoglobin at 2.0 Å resolution.

Authors:  Jun Yi; Leonard M Thomas; George B Richter-Addo
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2011-05-24

2.  Effects of T- and R-state stabilization on deoxyhemoglobin-nitrite reactions and stimulation of nitric oxide signaling.

Authors:  Nadiezhda Cantu-Medellin; Dario A Vitturi; Cilina Rodriguez; Serena Murphy; Scott Dorman; Sruti Shiva; Yipin Zhou; Yiping Jia; Andre F Palmer; Rakesh P Patel
Journal:  Nitric Oxide       Date:  2011-01-26       Impact factor: 4.427

3.  Linkage isomerization in heme-NOx compounds: understanding NO, nitrite, and hyponitrite interactions with iron porphyrins.

Authors:  Nan Xu; Jun Yi; George B Richter-Addo
Journal:  Inorg Chem       Date:  2010-07-19       Impact factor: 5.165

4.  Structural and Mechanistic Insights into Hemoglobin-catalyzed Hydrogen Sulfide Oxidation and the Fate of Polysulfide Products.

Authors:  Victor Vitvitsky; Pramod K Yadav; Sojin An; Javier Seravalli; Uhn-Soo Cho; Ruma Banerjee
Journal:  J Biol Chem       Date:  2017-02-17       Impact factor: 5.157

5.  Crystallographic characterization of the nitric oxide derivative of R-state human hemoglobin.

Authors:  Jun Yi; Alexei S Soares; George B Richter-Addo
Journal:  Nitric Oxide       Date:  2014-04-22       Impact factor: 4.427

6.  Structural features promoting dioxygen production by Dechloromonas aromatica chlorite dismutase.

Authors:  Brandon R Goblirsch; Bennett R Streit; Jennifer L Dubois; Carrie M Wilmot
Journal:  J Biol Inorg Chem       Date:  2010-04-13       Impact factor: 3.358

7.  Crystallographic trapping of heme loss intermediates during the nitrite-induced degradation of human hemoglobin.

Authors:  Jun Yi; Leonard M Thomas; Faik N Musayev; Martin K Safo; George B Richter-Addo
Journal:  Biochemistry       Date:  2011-09-06       Impact factor: 3.162

Review 8.  Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy.

Authors:  Dario A Vitturi; Rakesh P Patel
Journal:  Free Radic Biol Med       Date:  2011-06-16       Impact factor: 7.376

9.  The distal pocket histidine residue in horse heart myoglobin directs the O-binding mode of nitrite to the heme iron.

Authors:  Jun Yi; Julie Heinecke; Hui Tan; Peter C Ford; George B Richter-Addo
Journal:  J Am Chem Soc       Date:  2009-12-23       Impact factor: 15.419

10.  Generating S-nitrosothiols from hemoglobin: mechanisms, conformational dependence, and physiological relevance.

Authors:  Camille J Roche; Maria B Cassera; David Dantsker; Rhoda Elison Hirsch; Joel M Friedman
Journal:  J Biol Chem       Date:  2013-06-17       Impact factor: 5.157
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