Literature DB >> 18627273

Role of nitric oxide in defense of the central nervous system against Mycobacterium tuberculosis.

Michael R Olin1, Aníbal G Armién, Maxim C-J Cheeran, R Bryan Rock, Thomas W Molitor, Phillip K Peterson.   

Abstract

Murine models of tuberculous meningitis (TBM) have not reflected the severity of disease in humans. Based on reports that activated murine microglial cells, but not human microglial cells, express inducible nitric oxide synthase (iNOS), the objective of this study was to determine whether iNOS-knockout (iNOS(-/-)) mice would provide such a model. iNOS(-/-) mice infected with M. tuberculosis developed serious clinical manifestations and granulomatous lesions containing tubercle bacilli throughout the meninges, all of which were absent in wild-type mice. This study underscores the importance of nitric oxide in defense against TBM and suggests that iNOS(-/-) mice are an appropriate model for human TBM.

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Year:  2008        PMID： 18627273      PMCID： PMC7580555          DOI： 10.1086/591097

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  13 in total

1.  Differential microbial clearance and immunoresponse of Balb/c (Nramp1 susceptible) and DBA2 (Nramp1 resistant) mice intracerebrally infected with Mycobacterium bovis BCG (BCG).

Authors:  Rosanna Mazzolla; Manuela Puliti; Roberta Barluzzi; Rachele Neglia; Francesco Bistoni; Giuseppe Barbolini; Elisabetta Blasi
Journal:  FEMS Immunol Med Microbiol       Date:  2002-01-14

2.  Mycobacterium tuberculosis-induced cytokine and chemokine expression by human microglia and astrocytes: effects of dexamethasone.

Authors:  R Bryan Rock; Shuxian Hu; Genya Gekker; Wen S Sheng; Barbara May; Vivek Kapur; Phillip K Peterson
Journal:  J Infect Dis       Date:  2005-11-09       Impact factor: 5.226

Review 3.  Role of microglia in central nervous system infections.

Authors:  R Bryan Rock; Genya Gekker; Shuxian Hu; Wen S Sheng; Maxim Cheeran; James R Lokensgard; Phillip K Peterson
Journal:  Clin Microbiol Rev       Date:  2004-10       Impact factor: 26.132

4.  Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response.

Authors:  Philip T Liu; Steffen Stenger; Huiying Li; Linda Wenzel; Belinda H Tan; Stephan R Krutzik; Maria Teresa Ochoa; Jürgen Schauber; Kent Wu; Christoph Meinken; Diane L Kamen; Manfred Wagner; Robert Bals; Andreas Steinmeyer; Ulrich Zügel; Richard L Gallo; David Eisenberg; Martin Hewison; Bruce W Hollis; John S Adams; Barry R Bloom; Robert L Modlin
Journal:  Science       Date:  2006-02-23       Impact factor: 47.728

Review 5.  What is the role of nitric oxide in murine and human host defense against tuberculosis?Current knowledge.

Authors:  E D Chan; J Chan; N W Schluger
Journal:  Am J Respir Cell Mol Biol       Date:  2001-11       Impact factor: 6.914

6.  A combination of thalidomide plus antibiotics protects rabbits from mycobacterial meningitis-associated death.

Authors:  L Tsenova; K Sokol; V H Freedman; G Kaplan
Journal:  J Infect Dis       Date:  1998-06       Impact factor: 5.226

7.  Transcriptional response of human microglial cells to interferon-gamma.

Authors:  R B Rock; S Hu; A Deshpande; S Munir; B J May; C A Baker; P K Peterson; V Kapur
Journal:  Genes Immun       Date:  2005-12       Impact factor: 2.676

8.  A new murine model to study the pathogenesis of tuberculous meningitis.

Authors:  Gijs Th J van Well; Catharina W Wieland; Sandrine Florquin; John J Roord; Tom van der Poll; A Marceline van Furth
Journal:  J Infect Dis       Date:  2007-01-22       Impact factor: 5.226

9.  Nitric oxide production and neurotoxicity mediated by activated microglia from human versus mouse brain.

Authors:  P K Peterson; S Hu; W R Anderson; C C Chao
Journal:  J Infect Dis       Date:  1994-08       Impact factor: 5.226

10.  Inhibition of nitric oxide synthesis increases mortality in Sindbis virus encephalitis.

Authors:  P C Tucker; D E Griffin; S Choi; N Bui; S Wesselingh
Journal:  J Virol       Date:  1996-06       Impact factor: 5.103
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  4 in total

Review 1.  Does Concurrent Use of Some Botanicals Interfere with Treatment of Tuberculosis?

Authors:  William R Folk; Aaron Smith; Hailong Song; Dennis Chuang; Jianlin Cheng; Zezong Gu; Grace Sun
Journal:  Neuromolecular Med       Date:  2016-05-07       Impact factor: 3.843

2.  Myeloid and T Cell-Derived TNF Protects against Central Nervous System Tuberculosis.

Authors:  Nai-Jen Hsu; Ngiambudulu M Francisco; Roanne Keeton; Nasiema Allie; Valérie F J Quesniaux; Bernhard Ryffel; Muazzam Jacobs
Journal:  Front Immunol       Date:  2017-02-23       Impact factor: 7.561

3.  Nos2-/- mice infected with M. tuberculosis develop neurobehavioral changes and immunopathology mimicking human central nervous system tuberculosis.

Authors:  Xuan Ying Poh; Jia Mei Hong; Chen Bai; Qing Hao Miow; Pei Min Thong; Yu Wang; Ravisankar Rajarethinam; Cristine S L Ding; Catherine W M Ong
Journal:  J Neuroinflammation       Date:  2022-01-24       Impact factor: 9.587

4.  The role of nitric oxide in mycobacterial infections.

Authors:  Chul-Su Yang; Jae-Min Yuk; Eun-Kyeong Jo
Journal:  Immune Netw       Date:  2009-04-30       Impact factor: 6.303
  4 in total

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