| Literature DB >> 17262711 |
Gijs Th J van Well1, Catharina W Wieland, Sandrine Florquin, John J Roord, Tom van der Poll, A Marceline van Furth.
Abstract
Tuberculous meningitis (TM) is a severe complication of tuberculosis that mainly occurs during childhood. No murine models are available to study this disease. The purpose of the present study was to develop a murine model to investigate the pathogenesis of TM. Mice were intracerebrally injected with Mycobacterium tuberculosis. Bacilli could be cultured from brain homogenates, and, on histopathological examination, all mice were found to have meningeal cellular infiltration. We found elevated levels of chemoattractants for mononuclear phagocytes and neutrophilic granulocytes. This is the first murine model for TM that can be used for research on the host response to TM, in particular the innate immune response.Entities:
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Year: 2007 PMID： 17262711 DOI： 10.1086/511273
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226