Literature DB >> 18625776

Real-time PCR and statistical analyses of acrAB and ramA expression in clinical isolates of Klebsiella pneumoniae.

Alexey Ruzin1, Frederick W Immermann, Patricia A Bradford.   

Abstract

Clinical isolates of Klebsiella pneumoniae were tested for a correlation between tigecycline MIC and expression of ramA by using real-time PCR. At MICs of 4 and 8 microg/ml, the expression of ramA was statistically significantly different from MICs of 2 microg/ml or less, supporting the tigecycline susceptibility breakpoint of <or=2 microg/ml for K. pneumoniae.

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Year:  2008        PMID： 18625776      PMCID： PMC2533484          DOI： 10.1128/AAC.00591-08

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  9 in total

1.  Establishing MIC breakpoints and the interpretation of in vitro susceptibility tests.

Authors:  A P MacGowan; R Wise
Journal:  J Antimicrob Chemother       Date:  2001-07       Impact factor: 5.790

2.  Influence of transcriptional activator RamA on expression of multidrug efflux pump AcrAB and tigecycline susceptibility in Klebsiella pneumoniae.

Authors:  Alexey Ruzin; Melissa A Visalli; David Keeney; Patricia A Bradford
Journal:  Antimicrob Agents Chemother       Date:  2005-03       Impact factor: 5.191

3.  In vitro and in vivo antibacterial activities of a novel glycylcycline, the 9-t-butylglycylamido derivative of minocycline (GAR-936).

Authors:  P J Petersen; N V Jacobus; W J Weiss; P E Sum; R T Testa
Journal:  Antimicrob Agents Chemother       Date:  1999-04       Impact factor: 5.191

4.  AcrAB efflux pump plays a role in decreased susceptibility to tigecycline in Morganella morganii.

Authors:  Alexey Ruzin; David Keeney; Patricia A Bradford
Journal:  Antimicrob Agents Chemother       Date:  2005-02       Impact factor: 5.191

5.  Efflux-mediated resistance to tigecycline (GAR-936) in Pseudomonas aeruginosa PAO1.

Authors:  Charles R Dean; Melissa A Visalli; Steven J Projan; Phaik-Eng Sum; Patricia A Bradford
Journal:  Antimicrob Agents Chemother       Date:  2003-03       Impact factor: 5.191

6.  MarA-mediated overexpression of the AcrAB efflux pump results in decreased susceptibility to tigecycline in Escherichia coli.

Authors:  David Keeney; Alexey Ruzin; Fionnuala McAleese; Ellen Murphy; Patricia A Bradford
Journal:  J Antimicrob Chemother       Date:  2007-10-29       Impact factor: 5.790

7.  AcrAB multidrug efflux pump is associated with reduced levels of susceptibility to tigecycline (GAR-936) in Proteus mirabilis.

Authors:  Melissa A Visalli; Ellen Murphy; Steven J Projan; Patricia A Bradford
Journal:  Antimicrob Agents Chemother       Date:  2003-02       Impact factor: 5.191

8.  AdeABC multidrug efflux pump is associated with decreased susceptibility to tigecycline in Acinetobacter calcoaceticus-Acinetobacter baumannii complex.

Authors:  Alexey Ruzin; David Keeney; Patricia A Bradford
Journal:  J Antimicrob Chemother       Date:  2007-03-15       Impact factor: 5.790

9.  RamA, a transcriptional regulator, and AcrAB, an RND-type efflux pump, are associated with decreased susceptibility to tigecycline in Enterobacter cloacae.

Authors:  David Keeney; Alexey Ruzin; Patricia A Bradford
Journal:  Microb Drug Resist       Date:  2007       Impact factor: 3.431
  9 in total
  25 in total

1.  In vivo emergence of tigecycline resistance in multidrug-resistant Klebsiella pneumoniae and Escherichia coli.

Authors:  Teresa Spanu; Giulia De Angelis; Michela Cipriani; Barbara Pedruzzi; Tiziana D'Inzeo; Maria Adriana Cataldo; Gabriele Sganga; Evelina Tacconelli
Journal:  Antimicrob Agents Chemother       Date:  2012-05-29       Impact factor: 5.191

2.  ramR mutations in clinical isolates of Klebsiella pneumoniae with reduced susceptibility to tigecycline.

Authors:  M Hentschke; M Wolters; I Sobottka; H Rohde; M Aepfelbacher
Journal:  Antimicrob Agents Chemother       Date:  2010-03-29       Impact factor: 5.191

3.  Tigecycline resistance among Klebsiella pneumoniae isolated from febrile neutropenic patients.

Authors:  Sherein G Elgendy; Muhammad R Abdel Hameed; Mohamed A El-Mokhtar
Journal:  J Med Microbiol       Date:  2018-05-25       Impact factor: 2.472

Review 4.  The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria.

Authors:  Xian-Zhi Li; Patrick Plésiat; Hiroshi Nikaido
Journal:  Clin Microbiol Rev       Date:  2015-04       Impact factor: 26.132

5.  Highly Tigecycline-Resistant Klebsiella pneumoniae Sequence Type 11 (ST11) and ST147 Isolates from Companion Animals.

Authors:  Cristina M Ovejero; Jose Antonio Escudero; Daniel Thomas-Lopez; Andreas Hoefer; Gabriel Moyano; Natalia Montero; Carmen Martin-Espada; Bruno Gonzalez-Zorn
Journal:  Antimicrob Agents Chemother       Date:  2017-05-24       Impact factor: 5.191

6.  Mode of Action of the Monobactam LYS228 and Mechanisms Decreasing In Vitro Susceptibility in Escherichia coli and Klebsiella pneumoniae.

Authors:  Charles R Dean; David T Barkan; Alun Bermingham; Johanne Blais; Fergal Casey; Anthony Casarez; Richard Colvin; John Fuller; Adriana K Jones; Cindy Li; Sara Lopez; Louis E Metzger; Mina Mostafavi; Ramadevi Prathapam; Dita Rasper; Folkert Reck; Alexey Ruzin; Jacob Shaul; Xiaoyu Shen; Robert L Simmons; Peter Skewes-Cox; Kenneth T Takeoka; Pramila Tamrakar; Tsuyoshi Uehara; Jun-Rong Wei
Journal:  Antimicrob Agents Chemother       Date:  2018-09-24       Impact factor: 5.191

Review 7.  Tetracycline Antibiotics and Resistance.

Authors:  Trudy H Grossman
Journal:  Cold Spring Harb Perspect Med       Date:  2016-04-01       Impact factor: 6.915

8.  IS5 element integration, a novel mechanism for rapid in vivo emergence of tigecycline nonsusceptibility in Klebsiella pneumoniae.

Authors:  Lindsey E Nielsen; Erik C Snesrud; Fatma Onmus-Leone; Yoon I Kwak; Ricardo Avilés; Eric D Steele; Deena E Sutter; Paige E Waterman; Emil P Lesho
Journal:  Antimicrob Agents Chemother       Date:  2014-08-04       Impact factor: 5.191

9.  AraC/XylS family stress response regulators Rob, SoxS, PliA, and OpiA in the fire blight pathogen Erwinia amylovora.

Authors:  Daniel Pletzer; Gabriel Schweizer; Helge Weingart
Journal:  J Bacteriol       Date:  2014-06-16       Impact factor: 3.490

10.  Correlation of the expression of acrB and the regulatory genes marA, soxS and ramA with antimicrobial resistance in clinical isolates of Klebsiella pneumoniae endemic to New York City.

Authors:  Simona Bratu; David Landman; Avrille George; Jerome Salvani; John Quale
Journal:  J Antimicrob Chemother       Date:  2009-05-20       Impact factor: 5.790
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