Fei Wang1, Jessica H Kalmar2, Elliot Kale Edmiston2, Lara G Chepenik2, Zubin Bhagwagar3, Linda Spencer2, Brian Pittman3, Marcel Jackowski4, Xenophon Papademetris5, R Todd Constable6, Hilary P Blumberg7. 1. Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut; Department of Psychiatry, VA CT Healthcare System, West Haven, Connecticut. Electronic address: fei.wang@yale.edu. 2. Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut; Department of Psychiatry, VA CT Healthcare System, West Haven, Connecticut. 3. Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut. 4. Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut; Institute of Mathematics and Statistics, University of São Paulo, Brazil. 5. Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut; Department of Biomedical Engineering, Yale University School of Medicine, New Haven, Connecticut. 6. Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut; Department of Biomedical Engineering, Yale University School of Medicine, New Haven, Connecticut; Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut. 7. Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut; Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut; Department of Psychiatry, VA CT Healthcare System, West Haven, Connecticut.
Abstract
OBJECTIVE: Abnormalities in the anterior interhemispheric connections provided by the corpus callosum (CC) have long been implicated in bipolar disorder (BD). In this study, we used complementary diffusion tensor imaging methods to study the structural integrity of the CC and localization of potential abnormalities in BD. METHODS: Subjects included 33 participants with BD and 40 healthy comparison participants. Fractional anisotropy (FA) measures were compared between groups with region of interest (ROI) methods to investigate the anterior, middle, and posterior CC and voxel-based methods to further localize abnormalities. RESULTS: In ROI-based analyses, FA was significantly decreased in the anterior and middle CC in the BD group (p < .05). Voxel-based analyses similarly localized group differences to the genu, rostral body, and anterior midbody of CC (p < .05, corrected). CONCLUSION: The findings demonstrate abnormalities in the structural integrity of the anterior CC in BD that might contribute to altered interhemispheric connectivity in this disorder.
OBJECTIVE: Abnormalities in the anterior interhemispheric connections provided by the corpus callosum (CC) have long been implicated in bipolar disorder (BD). In this study, we used complementary diffusion tensor imaging methods to study the structural integrity of the CC and localization of potential abnormalities in BD. METHODS: Subjects included 33 participants with BD and 40 healthy comparison participants. Fractional anisotropy (FA) measures were compared between groups with region of interest (ROI) methods to investigate the anterior, middle, and posterior CC and voxel-based methods to further localize abnormalities. RESULTS: In ROI-based analyses, FA was significantly decreased in the anterior and middle CC in the BD group (p < .05). Voxel-based analyses similarly localized group differences to the genu, rostral body, and anterior midbody of CC (p < .05, corrected). CONCLUSION: The findings demonstrate abnormalities in the structural integrity of the anterior CC in BD that might contribute to altered interhemispheric connectivity in this disorder.
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