| Literature DB >> 18619816 |
Kyung-Min Choi1, Jingu Gang, Jisoo Yun.
Abstract
Methanolic extracts of 15 traditional medicines used to treat Toxoplasma gondii were tested in vitro for their anti-T. gondii activity and cytotoxicity. The median effective concentration (EC(50)) values for the herbal extracts ranged from 0.11mg/mL to 2.28mg/mL. Significant anti-T. gondii RH strain activity was observed with Zingiber officinale extracts (EC(50)=0.18mg/mL), which displayed a highly selective toxicity (selectivity=10.1). Sophora flavescens Aiton extracts also showed high anti-T. gondii activity (EC(50)=0.20mg/mL) and a high selective toxicity (4.6). This indicates that Z. officinale and S. flavescens Aiton extracts may be sources of new anti-T. gondii compounds.Entities:
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Year: 2008 PMID： 18619816 DOI： 10.1016/j.ijantimicag.2008.04.012
Source DB: PubMed Journal: Int J Antimicrob Agents ISSN： 0924-8579 Impact factor: 5.283