Kourosh Cheraghipour1, Leila Masoori1, Behrooz Ezzatpour1, Mona Roozbehani2, Ali Sheikhian1, Vahid Malekara1, Massumeh Niazi3, Omid Mardanshah4, Kobra Moradpour5, Hossein Mahmoudvand6. 1. Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran. 2. Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. 3. Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran. 4. Department of Laboratory Sciences, School of Medical Sciences, Sirjan Faculty of Medical Sciences, Kerman, Iran. 5. Lorestan University of Medical Sciences, Khorramabad, Iran. 6. Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran. dmahmodvand@gmail.com.
Abstract
BACKGROUND: Toxoplasma gondii is the global protozoa that could cause contamination in warm-blooded animals and is considered among the opportunistic pathogens in immunocompromised patients. Among the people at risk, toxoplasmosis infection can lead to the incidence of severe clinical manifestations, encephalitis, chorioretinitis, and even death. PURPOSE: The present research is focused on the new research for the treatment of toxoplasmosis parasitic disease using medicinal herbs. METHODS: The search was performed in five English databases, including Scopus, PubMed, Web of Science, EMBASE, and Google Scholar up from 2010 to December 2019. Studies in any language were entered in the searching step if they had an English abstract. The words and terms were used as a syntax with specific tags of each database. RESULTS: Out of 1832 studies, 36 were eligible to be reviewed. The findings showed that 17 studies (47%) were performed in vitro, 14 studies (39%) in vivo, and 5 studies (14%) both in vivo and in vitro. CONCLUSION: The studies showed that the plant extracts can be a good alternative in reducing the toxoplasmosis effects in the host and the herbal extracts can be used to produce natural product-based drugs affecting toxoplasmosis with fewer side-effects than synthetic drugs.
BACKGROUND:Toxoplasma gondii is the global protozoa that could cause contamination in warm-blooded animals and is considered among the opportunistic pathogens in immunocompromised patients. Among the people at risk, toxoplasmosis infection can lead to the incidence of severe clinical manifestations, encephalitis, chorioretinitis, and even death. PURPOSE: The present research is focused on the new research for the treatment of toxoplasmosis parasitic disease using medicinal herbs. METHODS: The search was performed in five English databases, including Scopus, PubMed, Web of Science, EMBASE, and Google Scholar up from 2010 to December 2019. Studies in any language were entered in the searching step if they had an English abstract. The words and terms were used as a syntax with specific tags of each database. RESULTS: Out of 1832 studies, 36 were eligible to be reviewed. The findings showed that 17 studies (47%) were performed in vitro, 14 studies (39%) in vivo, and 5 studies (14%) both in vivo and in vitro. CONCLUSION: The studies showed that the plant extracts can be a good alternative in reducing the toxoplasmosis effects in the host and the herbal extracts can be used to produce natural product-based drugs affecting toxoplasmosis with fewer side-effects than synthetic drugs.
Authors: P S Franco; A O Gomes; B F Barbosa; M B Angeloni; N M Silva; A Teixeira-Carvalho; O A Martins-Filho; D A O Silva; J R Mineo; E A V Ferro Journal: Placenta Date: 2011-09-09 Impact factor: 3.481
Authors: José M Ramos; Afredo Milla; Juan C Rodríguez; Sergio Padilla; Mar Masiá; Félix Gutiérrez Journal: Parasitol Res Date: 2011-05-04 Impact factor: 2.289