Literature DB >> 18619585

A convenient preparation of 6-oligo(lactic acid)cyclomaltoheptaose as kinetically degradable derivative for controlled release of amoxicillin.

Jian Shen1, Aiyou Hao, Guangyan Du, Huacheng Zhang, Hongyuan Sun.   

Abstract

6-Oligo(lactic acid)cyclomaltoheptaose (6-OLA-betaCD) with an average substitution of about 7.0 lactic acid units was prepared as a new water-soluble cyclomaltoheptaose (betaCD) derivative (solubility of about 70.7-fold that of betaCD), based on the ring-opening polymerization of 3,6-dimethyl-1,4-dioxane-2,5-dione (lactide). The product was characterized by (1)H NMR, (13)C NMR, IR, and MS spectroscopy. The complexation of amoxicillin with 6-OLA-betaCD was found to be much stronger than that with betaCD at first, and then 6-OLA-betaCD was shown to decompose moderately into betaCD and lactic acid. 6-OLA-betaCD might be greatly valuable in a controlled release system for Amoxicillin (AMX).

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Year:  2008        PMID： 18619585     DOI： 10.1016/j.carres.2008.06.010

Source DB:  PubMed          Journal:  Carbohydr Res        ISSN： 0008-6215            Impact factor:   2.104


  6 in total

1.  Cyclodextrins tethered with oligolactides - green synthesis and structural assessment.

Authors:  Cristian Peptu; Mihaela Balan-Porcarasu; Alena Šišková; Ľudovít Škultéty; Jaroslav Mosnáček
Journal:  Beilstein J Org Chem       Date:  2017-04-26       Impact factor: 2.883

Review 2.  Modification of Oligo- and Polylactides With Macrocyclic Fragments: Synthesis and Properties.

Authors:  Olga A Mostovaya; Vladimir V Gorbachuk; Pavel L Padnya; Alena A Vavilova; Gennady A Evtugyn; Ivan I Stoikov
Journal:  Front Chem       Date:  2019-08-02       Impact factor: 5.221

3.  Cyclodextrins Initiated Ring-Opening Polymerization of Lactide Using 4-Dimethylaminopyridine (DMAP) as Catalyst: Study of DMAP/β-CD Inclusion Complex and Access to New Structures.

Authors:  Julie Meimoun; Yupin Phuphuak; Remi Miyamachi; Yong Miao; Marc Bria; Cyril Rousseau; Guilherme Nogueira; Andreia Valente; Audrey Favrelle-Huret; Philippe Zinck
Journal:  Molecules       Date:  2022-02-06       Impact factor: 4.411

4.  Cyclodextrin-Oligocaprolactone Derivatives-Synthesis and Advanced Structural Characterization by MALDI Mass Spectrometry.

Authors:  Cristian Peptu; Diana-Andreea Blaj; Mihaela Balan-Porcarasu; Joanna Rydz
Journal:  Polymers (Basel)       Date:  2022-03-31       Impact factor: 4.329

5.  The Influence of the Hydroxyl Type on Crosslinking Process in Cyclodextrin Based Polyurethane Networks.

Authors:  Cristian Peptu; Alexandra-Diana Diaconu; Maricel Danu; Catalina A Peptu; Mariana Cristea; Valeria Harabagiu
Journal:  Gels       Date:  2022-06-02

6.  Structural Architectural Features of Cyclodextrin Oligoesters Revealed by Fragmentation Mass Spectrometry Analysis.

Authors:  Cristian Peptu; Maksym Danchenko; Ľudovít Škultéty; Jaroslav Mosnáček
Journal:  Molecules       Date:  2018-09-05       Impact factor: 4.411
  6 in total

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