Literature DB >> 18617349

HPLC-electrospray mass spectrometric assay for the determination of (R,R)-fenoterol in rat plasma.

Danuta Siluk1, Hee Seung Kim, Tyler Cole, Irving W Wainer.   

Abstract

A fast and specific liquid chromatography-mass spectrometry method for the determination of (R,R)-fenoterol ((R,R)-Fen) in rat plasma has been developed and validated. (R,R)-Fen was extracted from 125 microl of plasma using solid phase extraction and analyzed on Atlantis HILIC Silica 3 microm column. The mobile phase was composed of acetonitrile:ammonium acetate (pH 4.1; 20mM) (85:15, v/v), at a flow rate of 0.2 ml/min. The lower limit of detection (LLOD) was 2 ng/ml . The procedure was validated and applied to the analysis of plasma samples from rats previously administered (R,R)-Fen in an intravenous bolus.

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Year:  2008        PMID： 18617349      PMCID： PMC2574940          DOI： 10.1016/j.jpba.2008.05.034

Source DB:  PubMed          Journal:  J Pharm Biomed Anal        ISSN： 0731-7085            Impact factor:   3.935


  11 in total

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5.  Gas chromatographic-mass spectrometric determination of beta 2-agonists in postmortem blood: application in forensic medicine.

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6.  High-performance liquid chromatographic determination of the beta2-selective adrenergic agonist fenoterol in human plasma after fluorescence derivatization.

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7.  Enantioselective separation and online affinity chromatographic characterization of R,R- and S,S-fenoterol.

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8.  Determination of fenoterol and ractopamine in urine by enzyme immunoassay.

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10.  Comparative molecular field analysis of the binding of the stereoisomers of fenoterol and fenoterol derivatives to the beta2 adrenergic receptor.

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  3 in total

1.  Development and validation of a sensitive LC-MS/MS method for the determination of fenoterol in human plasma and urine samples.

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2.  Quantitative determination of fenoterol and fenoterol derivatives in rat plasma using on-line immunoextraction and liquid chromatography/mass spectrometry.

Authors:  Hee Seung Kim; Danuta Siluk; Irving W Wainer
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3.  Pharmacokinetics and metabolism of (R,R)-methoxyfenoterol in rat.

Authors:  D Siluk; D E Mager; H S Kim; Y Wang; A M Furimsky; A Ta; L V Iyer; C E Green; I W Wainer
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  3 in total

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