Literature DB >> 18615280

alpha-Glucosidase inhibitory activity of cyanidin-3-galactoside and synergistic effect with acarbose.

Sirichai Adisakwattana1, Piyawan Charoenlertkul, Sirintorn Yibchok-Anun.   

Abstract

Cyanidin-3-galactoside, a natural anthocyanin, was investigated for its alpha-glucosidase inhibitory activity. The IC(50) value of cyanidin-3-galactoside was 0.50 +/- 0.05 mM against intestinal sucrase. A low dose of cyanidin-3-galactoside showed a synergistic inhibition on intestinal alpha-glucosidase (maltase and sucrase) when combined with acarbose. A kinetic analysis showed that cyanidin-3-galactoside gave a mixed type inhibition against intestinal sucrase. The results indicated that cyanidin-3-galactoside was an alpha-glucosidase inhibitor and could be used in combination with acarbose for treatment of diabetes.

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Year:  2009        PMID： 18615280     DOI： 10.1080/14756360801906947

Source DB:  PubMed          Journal:  J Enzyme Inhib Med Chem        ISSN： 1475-6366            Impact factor:   5.051


  17 in total

1.  Anthocyanins of Pithecellobium dulce (Roxb.) Benth. Fruit Associated with High Antioxidant and α-Glucosidase Inhibitory Activities.

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Review 2.  Impact of dietary polyphenols on carbohydrate metabolism.

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Journal:  Int J Mol Sci       Date:  2010-03-31       Impact factor: 5.923

3.  Inhibitory activities of cyanidin and its glycosides and synergistic effect with acarbose against intestinal α-glucosidase and pancreatic α-amylase.

Authors:  Sarinya Akkarachiyasit; Piyawan Charoenlertkul; Sirintorn Yibchok-Anun; Sirichai Adisakwattana
Journal:  Int J Mol Sci       Date:  2010-09-20       Impact factor: 5.923

4.  Antioxidant rich grape pomace extract suppresses postprandial hyperglycemia in diabetic mice by specifically inhibiting alpha-glucosidase.

Authors:  Shelly Hogan; Lei Zhang; Jianrong Li; Shi Sun; Corene Canning; Kequan Zhou
Journal:  Nutr Metab (Lond)       Date:  2010-08-27       Impact factor: 4.169

5.  Cyanidin-3-O-β-glucoside and protocatechuic acid exert insulin-like effects by upregulating PPARγ activity in human omental adipocytes.

Authors:  Beatrice Scazzocchio; Rosaria Varì; Carmelina Filesi; Massimo D'Archivio; Carmela Santangelo; Claudio Giovannini; Annunziata Iacovelli; Gianfranco Silecchia; Giovanni Li Volti; Fabio Galvano; Roberta Masella
Journal:  Diabetes       Date:  2011-07-25       Impact factor: 9.461

6.  Cyanidin-3-rutinoside alleviates postprandial hyperglycemia and its synergism with acarbose by inhibition of intestinal α-glucosidase.

Authors:  Sirichai Adisakwattana; Sirintorn Yibchok-Anun; Piyawan Charoenlertkul; Natthakarn Wongsasiripat
Journal:  J Clin Biochem Nutr       Date:  2011-05-24       Impact factor: 3.114

7.  α-glucosidase inhibitors from plants: A natural approach to treat diabetes.

Authors:  Sunil Kumar; Smita Narwal; Vipin Kumar; Om Prakash
Journal:  Pharmacogn Rev       Date:  2011-01

Review 8.  Modulation of glucose transporter protein by dietary flavonoids in type 2 diabetes mellitus.

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Journal:  Int J Biol Sci       Date:  2015-03-19       Impact factor: 6.580

Review 9.  Peripheral Pathways in the Food-Intake Control towards the Adipose-Intestinal Missing Link.

Authors:  Hugo Mendieta Zerón; Ma Victoria Domínguez García; María Del Socorro Camarillo Romero; Miriam V Flores-Merino
Journal:  Int J Endocrinol       Date:  2013-12-05       Impact factor: 3.257

10.  Inhibition of advanced glycation end products by red grape skin extract and its antioxidant activity.

Authors:  Nattha Jariyapamornkoon; Sirintorn Yibchok-anun; Sirichai Adisakwattana
Journal:  BMC Complement Altern Med       Date:  2013-07-12       Impact factor: 3.659
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