OBJECTIVE: To investigate the expression of MMP-2, TIMP-1, E-cadherin and beta-catenin in endometrial serous carcinoma (ESC), low-grade endometrial endometrioid carcinoma (EEC), and proliferative endometrium. METHODS: We performed an immunohistochemical study on 14 cases of ESC, 15 cases of low-grade EEC, and 10 cases of proliferative endometrium. RESULTS: Compared with low-grade EEC, ESC showed significantly increased MMP-2 and TIMP-1 expression, as well as decreased membranous beta-catenin staining. E-cadherin expression was significantly lower in ESC and EEC as compared with proliferative endometrium. CONCLUSIONS: We suggest that MMP-2 and TIMP-1 expression and loss of beta-catenin have a role in the pathogenesis and progression of ESC. Decreased E-cadherin may have an important role in the development of both ESC and EEC. Furthermore, the dissimilarities in MMP-2, TIMP-1, E-cadherin and beta-catenin expressions in ESC compared with EEC may be responsible, along with other factors, for their different biological behavior.
OBJECTIVE: To investigate the expression of MMP-2, TIMP-1, E-cadherin and beta-catenin in endometrial serous carcinoma (ESC), low-grade endometrial endometrioid carcinoma (EEC), and proliferative endometrium. METHODS: We performed an immunohistochemical study on 14 cases of ESC, 15 cases of low-grade EEC, and 10 cases of proliferative endometrium. RESULTS: Compared with low-grade EEC, ESC showed significantly increased MMP-2 and TIMP-1 expression, as well as decreased membranous beta-catenin staining. E-cadherin expression was significantly lower in ESC and EEC as compared with proliferative endometrium. CONCLUSIONS: We suggest that MMP-2 and TIMP-1 expression and loss of beta-catenin have a role in the pathogenesis and progression of ESC. Decreased E-cadherin may have an important role in the development of both ESC and EEC. Furthermore, the dissimilarities in MMP-2, TIMP-1, E-cadherin and beta-catenin expressions in ESC compared with EEC may be responsible, along with other factors, for their different biological behavior.
Authors: Mallory E Lindberg; Genna R Stodden; Mandy L King; James A MacLean; Jordan L Mann; Francesco J DeMayo; John P Lydon; Kanako Hayashi Journal: Biol Reprod Date: 2013-07-11 Impact factor: 4.285
Authors: Nicole C M Visser; Anneke A M van der Wurff; Johanna M A Pijnenborg; Leon F A G Massuger; Johan Bulten; Iris D Nagtegaal Journal: Virchows Arch Date: 2018-02-09 Impact factor: 4.064
Authors: G R Stodden; M E Lindberg; M L King; M Paquet; J A MacLean; J L Mann; F J DeMayo; J P Lydon; K Hayashi Journal: Oncogene Date: 2014-07-07 Impact factor: 9.867