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Literature DB >> 18606571

Failure to restore the Vgamma2-Jgamma1.2 repertoire in HIV-infected men receiving highly active antiretroviral therapy (HAART).

Andrew M Hebbeler¹, Nadia Propp, Cristiana Cairo, Haishan Li, Jean Saville Cummings, Lisa P Jacobson, Joseph B Margolick, C David Pauza.

Abstract

Gammadelta (gammadelta) T cells expressing the Vgamma2-Jgamma1.2Vdelta2 (Vgamma9-JPVdelta2, alternate nomenclature) T cell receptor (TCR) constitute the major peripheral blood population of gammadelta T cells in adult humans and are specifically depleted during human immunodeficiency virus (HIV) disease. Vgamma2-Jgamma1.2Vdelta2 T cells provide a convenient model for assessing the impact of antiretroviral therapy on cell populations that are not susceptible to direct infection because they do not express CD4 and depletion occurs by indirect mechanisms. We obtained longitudinal PBMC samples from 16 HIV-infected individuals who enrolled in the Multicenter AIDS Cohort Study (MACS) and were starting highly active antiretroviral therapy (HAART). Vgamma2-Jgamma1.2Vdelta2 T cells were depleted in these individuals as a result of HIV infection. Despite evidence for clinical benefits of HAART, the Vgamma2-Jgamma1.2Vdelta2 T cell repertoire did not recover after HAART initiation irrespective of treatment duration. These studies highlight important defects among cell subsets lost due to indirect effects of HIV.

Entities: CellLine Chemical Disease Gene Mutation Species

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Year: 2008 PMID： 18606571 PMCID： PMC2603626 DOI： 10.1016/j.clim.2008.04.008

Source DB: PubMed Journal: Clin Immunol ISSN： 1521-6616 Impact factor: 3.969

33 in total

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