Developments in neuroimaging for acute ischemic stroke: diagnostic and clinical trial applications.

Over the past several years, active investigation into neuroimaging in the setting of acute ischemic stroke has improved our understanding of and ability to visualize the dynamic pathophysiology of acute cerebrovascular disease. Efforts surrounding the application of multimodal CT and MRI have resulted in a growing body of data from systematic evaluations of different parameters, experience in the use of these techniques in guiding clinical decision making, and clinical trials employing neuroimaging for patient selection, for proof of principle, and as a surrogate outcome measure.