BACKGROUND: Alkaline phosphatase (ALP) is a biomarker for hepatobiliary and skeletal diseases. It is also raised in sepsis. In atherosclerotic plaques, ALP is expressed. Similar to C-reactive protein (CRP), it may be another marker of systemic inflammation. Therefore, we investigated their association in a Hong Kong Chinese population. METHODS: Plasma ALP and CRP were measured in 205 subjects (110 men, 95 women; age 55.2+/-11.6 years) in the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 cohort. RESULTS: The blood levels of ALP and CRP were significantly correlated (r=0.30, p<0.001), which was due to a significant correlation in women (r=0.43, p<0.001). In a multivariate model, CRP level was related to ALP (beta=0.18, p=0.008). After adjusting for confounding factors and other liver enzymes, the relationship between ALP and CRP remained significant in women (beta=0.28, p=0.019), but in men, ALP was not an independent determinant of CRP levels. CONCLUSIONS: ALP may be another marker of systemic inflammation, especially in women. Whether it provides clinical information additional to CRP requires further study.
BACKGROUND:Alkaline phosphatase (ALP) is a biomarker for hepatobiliary and skeletal diseases. It is also raised in sepsis. In atherosclerotic plaques, ALP is expressed. Similar to C-reactive protein (CRP), it may be another marker of systemic inflammation. Therefore, we investigated their association in a Hong Kong Chinese population. METHODS: Plasma ALP and CRP were measured in 205 subjects (110 men, 95 women; age 55.2+/-11.6 years) in the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 cohort. RESULTS: The blood levels of ALP and CRP were significantly correlated (r=0.30, p<0.001), which was due to a significant correlation in women (r=0.43, p<0.001). In a multivariate model, CRP level was related to ALP (beta=0.18, p=0.008). After adjusting for confounding factors and other liver enzymes, the relationship between ALP and CRP remained significant in women (beta=0.28, p=0.019), but in men, ALP was not an independent determinant of CRP levels. CONCLUSIONS:ALP may be another marker of systemic inflammation, especially in women. Whether it provides clinical information additional to CRP requires further study.
Authors: Sriharsha Damera; Kalani L Raphael; Bradley C Baird; Alfred K Cheung; Tom Greene; Srinivasan Beddhu Journal: Kidney Int Date: 2010-09-29 Impact factor: 10.612
Authors: Alakesh Bera; Eric Russ; Rahul M Jindal; Maura A Watson; Robert Nee; Ofer Eidelman; John Karaian; Harvey B Pollard; Meera Srivastava Journal: Adv J Urol Nephrol Date: 2020-03-03
Authors: Rebecca Filipowicz; Tom Greene; Guo Wei; Alfred K Cheung; Kalani L Raphael; Bradley C Baird; Srinivasan Beddhu Journal: Clin J Am Soc Nephrol Date: 2012-11-02 Impact factor: 8.237