Literature DB >> 18604447

Roles of Krüpel-like factor 4 in normal homeostasis, cancer and stem cells.

Paul M Evans1, Chunming Liu.   

Abstract

Krüpel-like factor 4 (KLF4) is a zinc finger-type transcription factor expressed in a variety of tissues, including the epithelium of the intestine and the skin, and it plays an important role in differentiation and cell cycle arrest. Depending on the gene targeted, KLF4 can both activate and repress transcription. Moreover, in certain cellular contexts, KLF4 can function as a tumor suppressor or an oncogene. Finally, KLF4 is important in reprogramming differentiated fibroblasts into inducible pluripotent stem cells, which highly resemble embryonic stem cells. This review summarizes what is known about the diverse functions of KLF4 as well as their molecular mechanisms.

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Year:  2008        PMID： 18604447      PMCID： PMC2668950          DOI： 10.1111/j.1745-7270.2008.00439.x

Source DB:  PubMed          Journal:  Acta Biochim Biophys Sin (Shanghai)        ISSN： 1672-9145            Impact factor:   3.848


  122 in total

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Journal:  Clin Cancer Res       Date:  2004-09-15       Impact factor: 12.531

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Authors:  L K Su; K W Kinzler; B Vogelstein; A C Preisinger; A R Moser; C Luongo; K A Gould; W F Dove
Journal:  Science       Date:  1992-05-01       Impact factor: 47.728

3.  A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse.

Authors:  A R Moser; H C Pitot; W F Dove
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4.  Identification of Krüppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer.

Authors:  Weidong Zhao; Irfan M Hisamuddin; Mandayam O Nandan; Brian A Babbin; Neil E Lamb; Vincent W Yang
Journal:  Oncogene       Date:  2004-01-15       Impact factor: 9.867

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6.  Role of anaerobic bacteria in the metabolic welfare of the colonic mucosa in man.

Authors:  W E Roediger
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7.  Transcription factor Sp1 expression is a significant predictor of survival in human gastric cancer.

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8.  Requirement of Krüppel-like factor 4 in preventing entry into mitosis following DNA damage.

Authors:  Hong S Yoon; Vincent W Yang
Journal:  J Biol Chem       Date:  2003-11-19       Impact factor: 5.157

9.  The Kruppel-like KLF4 transcription factor, a novel regulator of urokinase receptor expression, drives synthesis of this binding site in colonic crypt luminal surface epithelial cells.

Authors:  Heng Wang; Lin Yang; Md Saha Jamaluddin; Douglas D Boyd
Journal:  J Biol Chem       Date:  2004-03-18       Impact factor: 5.157

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Authors:  A Preiss; U B Rosenberg; A Kienlin; E Seifert; H Jäckle
Journal:  Nature       Date:  1985 Jan 3-9       Impact factor: 49.962
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  95 in total

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3.  Regulation of KLF4 turnover reveals an unexpected tissue-specific role of pVHL in tumorigenesis.

Authors:  Armin M Gamper; Xinxian Qiao; Jennifer Kim; Liyong Zhang; Michelle C DeSimone; W Kimryn Rathmell; Yong Wan
Journal:  Mol Cell       Date:  2012-01-27       Impact factor: 17.970

4.  KLF4 translation level is associated with differentiation stage of different pediatric leukemias in both cell lines and primary samples.

Authors:  Xiaoping Guo; Yongmin Tang
Journal:  Clin Exp Med       Date:  2012-05-17       Impact factor: 3.984

5.  Epigallocatechin-3-gallate regulates the expression of Kruppel-like factor 4 through myocyte enhancer factor 2A.

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Journal:  Cell Stress Chaperones       Date:  2013-07-25       Impact factor: 3.667

6.  Role of Krüppel-like factor 4 and heat shock protein 27 in cancer of the larynx.

Authors:  Jihad Karam; Marie Claude Fadous-Khalifé; Rita Tannous; Sally Fakhreddine; Marcel Massoud; Joseph Hadchity; Georges Aftimos; Elie Hadchity
Journal:  Mol Clin Oncol       Date:  2017-09-19

7.  Cooperative transcriptional activation by Klf4, Meis2, and Pbx1.

Authors:  Glen A Bjerke; Cathy Hyman-Walsh; David Wotton
Journal:  Mol Cell Biol       Date:  2011-07-11       Impact factor: 4.272

8.  Expression of Krüppel-like factor 4 in breast cancer tissues and its effects on the proliferation of breast cancer MDA-MB-231 cells.

Authors:  Xiang Song; Yue-Ming Xing; Wei Wu; Guo-Hua Cheng; Feng Xiao; Gang Jin; Ying Liu; Xin Zhao
Journal:  Exp Ther Med       Date:  2017-03-24       Impact factor: 2.447

9.  Krüppel-like factor 4 blocks tumor cell proliferation and promotes drug resistance in multiple myeloma.

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10.  Epigenetic regulation of caspase-3 gene expression in rat brain development.

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