Literature DB >> 2296722

A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse.

A R Moser1, H C Pitot, W F Dove.   

Abstract

In a pedigree derived from a mouse treated with the mutagen ethylnitrosourea, a mutation has been identified that predisposes to spontaneous intestinal cancer. The mutant gene was found to be dominantly expressed and fully penetrant. Affected mice developed multiple adenomas throughout the entire intestinal tract at an early age.

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Year:  1990        PMID： 2296722     DOI： 10.1126/science.2296722

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  563 in total

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