Literature DB >> 18601524

Monitoring Pc 4 photodynamic therapy in clinical trials of cutaneous T-cell lymphoma using noninvasive spectroscopy.

Tammy K Lee1, Elma D Baron, Thomas H Foster.   

Abstract

Silicon phthalocyanine Pc 4 photodynamic therapy (Pc 4-PDT) has emerged as a potentially effective treatment for cutaneous T-cell lymphoma (CTCL). Noninvasive reflectance and fluorescence spectroscopy before, during, and after PDT may provide useful dose metrics and enable therapy to be tailored to individual lesions. We present the design and implementation of a portable bedside spectroscopy system for initial clinical trials of Pc 4-PDT of CTCL. Reflectance and fluorescence spectra were obtained from an early stage CTCL patient throughout the course of the PDT treatment. Preliminary patient data show a significant effect of Pc 4 on the tissue absorption, modest Pc 4 photobleaching, and heterogeneity of Pc 4 within and between the lesions.

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Year:  2008        PMID： 18601524      PMCID： PMC2527126          DOI： 10.1117/1.2939068

Source DB:  PubMed          Journal:  J Biomed Opt        ISSN： 1083-3668            Impact factor:   3.170


  6 in total

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Review 4.  Mycosis fungoides.

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Review 5.  Photodynamic therapy with the phthalocyanine photosensitizer Pc 4: the case experience with preclinical mechanistic and early clinical-translational studies.

Authors:  Janine D Miller; Elma D Baron; Heather Scull; Andrew Hsia; Jeffrey C Berlin; Thomas McCormick; Valdir Colussi; Malcolm E Kenney; Kevin D Cooper; Nancy L Oleinick
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6.  Photodynamic therapy of non-melanoma malignant tumours of the skin using topical delta-amino levulinic acid sensitization and laser irradiation.

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  6 in total
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Review 1.  Photodynamic therapy in dermatology: a review.

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3.  Intratumor administration of the photosensitizer pc 4 affords photodynamic therapy efficacy and selectivity at short drug-light intervals.

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5.  Fluence rate-dependent photobleaching of intratumorally administered Pc 4 does not predict tumor growth delay.

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6.  Photodynamic therapy with the silicon phthalocyanine pc 4 induces apoptosis in mycosis fungoides and sezary syndrome.

Authors:  Minh Lam; Yoojin Lee; Min Deng; Andrew H Hsia; Kelly A Morrissey; Chunlin Yan; Kashif Azzizudin; Nancy L Oleinick; Thomas S McCormick; Kevin D Cooper; Elma D Baron
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8.  Targeted iron-oxide nanoparticle for photodynamic therapy and imaging of head and neck cancer.

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9.  Non-invasive monitoring of alternative splicing outcomes to identify candidate therapies for myotonic dystrophy type 1.

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  9 in total

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