Literature DB >> 18599436

Complementary functions of ATM and H2AX in development and suppression of genomic instability.

Shan Zha1, JoAnn Sekiguchi, James W Brush, Craig H Bassing, Frederick W Alt.   

Abstract

Upon DNA damage, histone H2AX is phosphorylated by ataxia-telangiectasia mutated (ATM) and other phosphoinositide 3-kinase-related protein kinases. To elucidate further the potential overlapping and unique functions of ATM and H2AX, we asked whether they have synergistic functions in the development and maintenance of genomic stability by inactivating both genes in mouse germ line. Combined ATM/H2AX deficiency caused embryonic lethality and dramatic cellular genomic instability. Mechanistically, severe genomic instability in the double-deficient cells is associated with a requirement for H2AX to repair oxidative DNA damage resulting from ATM deficiency. We discuss these findings in the context of synergies between ATM and other repair factors.

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Year:  2008        PMID： 18599436      PMCID： PMC2453730          DOI： 10.1073/pnas.0803520105

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  30 in total

1.  Genomic instability in mice lacking histone H2AX.

Authors:  Arkady Celeste; Simone Petersen; Peter J Romanienko; Oscar Fernandez-Capetillo; Hua Tang Chen; Olga A Sedelnikova; Bernardo Reina-San-Martin; Vincenzo Coppola; Eric Meffre; Michael J Difilippantonio; Christophe Redon; Duane R Pilch; Alexandru Olaru; Michael Eckhaus; R Daniel Camerini-Otero; Lino Tessarollo; Ferenc Livak; Katia Manova; William M Bonner; Michel C Nussenzweig; André Nussenzweig
Journal:  Science       Date:  2002-04-04       Impact factor: 47.728

Review 2.  11q deletions in hematological malignancies.

Authors:  O Monni; S Knuutila
Journal:  Leuk Lymphoma       Date:  2001-01

3.  Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation.

Authors:  Bo Xu; Seong-Tae Kim; Dae-Sik Lim; Michael B Kastan
Journal:  Mol Cell Biol       Date:  2002-02       Impact factor: 4.272

4.  Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX.

Authors:  Craig H Bassing; Katrin F Chua; JoAnn Sekiguchi; Heikyung Suh; Scott R Whitlow; James C Fleming; Brianna C Monroe; David N Ciccone; Catherine Yan; Katerina Vlasakova; David M Livingston; David O Ferguson; Ralph Scully; Frederick W Alt
Journal:  Proc Natl Acad Sci U S A       Date:  2002-05-28       Impact factor: 11.205

5.  Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.

Authors:  Takahisa Furuta; Haruyuki Takemura; Zhi-Yong Liao; Gregory J Aune; Christophe Redon; Olga A Sedelnikova; Duane R Pilch; Emmy P Rogakou; Arkady Celeste; Hua Tang Chen; Andre Nussenzweig; Mirit I Aladjem; William M Bonner; Yves Pommier
Journal:  J Biol Chem       Date:  2003-03-25       Impact factor: 5.157

6.  Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress.

Authors:  I M Ward; J Chen
Journal:  J Biol Chem       Date:  2001-10-22       Impact factor: 5.157

7.  Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors.

Authors:  Craig H Bassing; Heikyung Suh; David O Ferguson; Katrin F Chua; John Manis; Mark Eckersdorff; Megan Gleason; Rodrick Bronson; Charles Lee; Frederick W Alt
Journal:  Cell       Date:  2003-08-08       Impact factor: 41.582

Review 8.  ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage.

Authors:  Ari Barzilai; Galit Rotman; Yosef Shiloh
Journal:  DNA Repair (Amst)       Date:  2002-01-22

9.  Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice.

Authors:  P R Borghesani; F W Alt; A Bottaro; L Davidson; S Aksoy; G A Rathbun; T M Roberts; W Swat; R A Segal; Y Gu
Journal:  Proc Natl Acad Sci U S A       Date:  2000-03-28       Impact factor: 11.205

10.  DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination.

Authors:  Sonia Franco; Michael M Murphy; Gang Li; Tiffany Borjeson; Cristian Boboila; Frederick W Alt
Journal:  J Exp Med       Date:  2008-03-03       Impact factor: 14.307
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  66 in total

1.  Aberrant TCRδ rearrangement underlies the T-cell lymphocytopenia and t(12;14) translocation associated with ATM deficiency.

Authors:  Wenxia Jiang; Brian J Lee; Chen Li; Richard L Dubois; Monica Gostissa; Frederick W Alt; Shan Zha
Journal:  Blood       Date:  2015-02-26       Impact factor: 22.113

2.  A p53 axis regulates B cell receptor-triggered, innate immune system-driven B cell clonal expansion.

Authors:  Hyunjoo Lee; Shabirul Haque; Jennifer Nieto; Joshua Trott; John K Inman; Steven McCormick; Nicholas Chiorazzi; Patricia K A Mongini
Journal:  J Immunol       Date:  2012-05-18       Impact factor: 5.422

3.  B Cell-Specific Expression of Ataxia-Telangiectasia Mutated Protein Kinase Promotes Chronic Gammaherpesvirus Infection.

Authors:  Eric J Darrah; Joseph M Kulinski; Wadzanai P Mboko; Gang Xin; Laurent P Malherbe; Stephen B Gauld; Weiguo Cui; Vera L Tarakanova
Journal:  J Virol       Date:  2017-09-12       Impact factor: 5.103

4.  ATM facilitates mouse gammaherpesvirus reactivation from myeloid cells during chronic infection.

Authors:  Joseph M Kulinski; Eric J Darrah; Katarzyna A Broniowska; Wadzanai P Mboko; Bryan C Mounce; Laurent P Malherbe; John A Corbett; Stephen B Gauld; Vera L Tarakanova
Journal:  Virology       Date:  2015-05-21       Impact factor: 3.616

5.  A Murine Model of Chronic Lymphocytic Leukemia Based on B Cell-Restricted Expression of Sf3b1 Mutation and Atm Deletion.

Authors:  Shanye Yin; Rutendo G Gambe; Jing Sun; Aina Zurita Martinez; Zachary J Cartun; Fara Faye D Regis; Youzhong Wan; Jean Fan; Angela N Brooks; Sarah E M Herman; Elisa Ten Hacken; Amaro Taylor-Weiner; Laura Z Rassenti; Emanuela M Ghia; Thomas J Kipps; Esther A Obeng; Carrie L Cibulskis; Donna Neuberg; Dean R Campagna; Mark D Fleming; Benjamin L Ebert; Adrian Wiestner; Ignaty Leshchiner; James A DeCaprio; Gad Getz; Robin Reed; Ruben D Carrasco; Catherine J Wu; Lili Wang
Journal:  Cancer Cell       Date:  2019-01-31       Impact factor: 31.743

6.  Redundant and nonredundant functions of ATM and H2AX in αβ T-lineage lymphocytes.

Authors:  Bu Yin; Baeck-Seung Lee; Katherine S Yang-Iott; Barry P Sleckman; Craig H Bassing
Journal:  J Immunol       Date:  2012-06-22       Impact factor: 5.422

7.  Restoration of ATM Expression in DNA-PKcs-Deficient Cells Inhibits Signal End Joining.

Authors:  Jessica A Neal; Yao Xu; Masumi Abe; Eric Hendrickson; Katheryn Meek
Journal:  J Immunol       Date:  2016-02-26       Impact factor: 5.422

8.  The ATM Kinase Restrains Joining of Both VDJ Signal and Coding Ends.

Authors:  Katheryn Meek; Yao Xu; Caleb Bailie; Kefei Yu; Jessica A Neal
Journal:  J Immunol       Date:  2016-08-29       Impact factor: 5.422

9.  Aggressive chronic lymphocytic leukemia with elevated genomic complexity is associated with multiple gene defects in the response to DNA double-strand breaks.

Authors:  Peter Ouillette; Samuel Fossum; Brian Parkin; Li Ding; Paula Bockenstedt; Ammar Al-Zoubi; Kerby Shedden; Sami N Malek
Journal:  Clin Cancer Res       Date:  2010-01-19       Impact factor: 12.531

10.  Development of immunoglobulin lambda-chain-positive B cells, but not editing of immunoglobulin kappa-chain, depends on NF-kappaB signals.

Authors:  Emmanuel Derudder; Emily J Cadera; J Christoph Vahl; Jing Wang; Casey J Fox; Shan Zha; Geert van Loo; Manolis Pasparakis; Mark S Schlissel; Marc Schmidt-Supprian; Klaus Rajewsky
Journal:  Nat Immunol       Date:  2009-05-03       Impact factor: 25.606
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