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Literature DB >> 24444601

Identification of an arylalkylamine N-acyltransferase from Drosophila melanogaster that catalyzes the formation of long-chain N-acylserotonins.

Daniel R Dempsey¹, Kristen A Jeffries¹, Ryan L Anderson¹, Anne-Marie Carpenter¹, Santiago Rodriquez Opsina¹, David J Merkler².

Abstract

Arylalkylamine N-acyltransferase-like 2(2) (AANATL2) from Drosophila melanogaster was expressed and shown to catalyze the formation of long-chain N-acylserotonins and N-acydopamines. Subsequent identification of endogenous amounts of N-acylserotonins and colocalization of these fatty acid amides and AANATL2 transcripts gives supporting evidence that AANATL2 has a role in the biosynthetic formation of these important cell signalling lipids.

Entities: CellLine Chemical Disease Gene Species

Keywords: Arylalkylamine N-acetyltransferase; Arylalkylamine N-acyltransferase; Drosophila melanogaster; N-acyldopamine; N-acylserotonin; Steady-state kinetics; Thorax-abdomen

Mesh：

Substances：

Year: 2014 PMID： 24444601 PMCID： PMC3952154 DOI： 10.1016/j.febslet.2013.12.027

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

25 in total

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Authors: R Amherd; E Hintermann; D Walz; M Affolter; U A Meyer
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2. Presence, formation and putative biological activities of N-acyl serotonins, a novel class of fatty-acid derived mediators, in the intestinal tract.

Authors: Kitty C M Verhoeckx; Trudy Voortman; Michiel G J Balvers; Henk F J Hendriks; Heleen M Wortelboer; Renger F Witkamp
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3. Effect of endocannabinoids on soybean lipoxygenase-1 activity.

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Journal: Bioorg Chem Date: 2013-06-13 Impact factor: 5.275

4. N-acyl-dopamines: novel synthetic CB(1) cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo.

Authors: T Bisogno; D Melck; N M Gretskaya; V V Bezuglov; L De Petrocellis; V Di Marzo
Journal: Biochem J Date: 2000-11-01 Impact factor: 3.857

5. Substrate specificity and inhibition studies of human serotonin N-acetyltransferase.

Authors: G Ferry; A Loynel; N Kucharczyk; S Bertin; M Rodriguez; P Delagrange; J P Galizzi; E Jacoby; J P Volland; D Lesieur; P Renard; E Canet; J L Fauchère; J A Boutin
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Review 6. GCN5-related N-acetyltransferases: a structural overview.

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Journal: Annu Rev Biophys Biomol Struct Date: 2000

7. Primary fatty acid amide metabolism: conversion of fatty acids and an ethanolamine in N18TG2 and SCP cells.

Authors: Emma K Farrell; Yuden Chen; Muna Barazanji; Kristen A Jeffries; Felipe Cameroamortegui; David J Merkler
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Review 8. Serotonin N-acetyltransferase: mechanism and inhibition.

Authors: Weiping Zheng; Philip A Cole
Journal: Curr Med Chem Date: 2002-06 Impact factor: 4.530

9. Effect of endocannabinoids on IgE-mediated allergic response in RBL-2H3 cells.

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10. An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors.

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Journal: Proc Natl Acad Sci U S A Date: 2002-06-11 Impact factor: 11.205

19 in total

1. Drosophila melanogaster as a model system to study long-chain fatty acid amide metabolism.

Authors: Kristen A Jeffries; Daniel R Dempsey; Anita L Behari; Ryan L Anderson; David J Merkler
Journal: FEBS Lett Date: 2014-03-17 Impact factor: 4.124

Review 2. New approaches and challenges to targeting the endocannabinoid system.

Authors: Vincenzo Di Marzo
Journal: Nat Rev Drug Discov Date: 2018-08-17 Impact factor: 84.694

3. Probing the chemical mechanism and critical regulatory amino acid residues of Drosophila melanogaster arylalkylamine N-acyltransferase like 2.

Authors: Daniel R Dempsey; Anne-Marie Carpenter; Santiago Rodriguez Ospina; David J Merkler
Journal: Insect Biochem Mol Biol Date: 2015-10-21 Impact factor: 4.714

4. Mechanistic and Structural Analysis of a Drosophila melanogaster Enzyme, Arylalkylamine N-Acetyltransferase Like 7, an Enzyme That Catalyzes the Formation of N-Acetylarylalkylamides and N-Acetylhistamine.

Authors: Daniel R Dempsey; Kristen A Jeffries; Sumit Handa; Anne-Marie Carpenter; Santiago Rodriguez-Ospina; Leonid Breydo; David J Merkler
Journal: Biochemistry Date: 2015-04-16 Impact factor: 3.162