| Literature DB >> 18591799 |
Annett Mikolasch1, Martina Wurster, Michael Lalk, Sabine Witt, Simone Seefeldt, Elke Hammer, Frieder Schauer, Wolf-Dieter Jülich, Ulrike Lindequist.
Abstract
Novel cephalosporins, penicillins, and carbacephems were synthesized by amination of catechols with amino-beta-lactams like cefadroxil, amoxicillin, ampicillin and the structurally related carbacephem loracarbef using laccase from Trametes sp. All isolated monoaminated products inhibited the growth of several Gram positive bacterial strains in the agar diffusion assay, among them methicillin-resistant Staphylococcus aureus strains and vancomycin-resistant Enterococci. Observed differences in the cytotoxicity and in vivo activity in a "Staphylococcus-infected, immune suppressed mouse" model are discussed.Entities:
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Year: 2008 PMID： 18591799 DOI： 10.1248/cpb.56.902
Source DB: PubMed Journal: Chem Pharm Bull (Tokyo) ISSN： 0009-2363 Impact factor: 1.645