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Literature DB >> 18586491

Gallic acid-based indanone derivatives as anticancer agents.

Hari Om Saxena¹, Uzma Faridi, Suchita Srivastava, J K Kumar, M P Darokar, Suaib Luqman, C S Chanotiya, Vinay Krishna, Arvind S Negi, S P S Khanuja.

Abstract

Gallic acid-based indanone derivatives have been synthesised. Some of the indanones showed very good anticancer activity in MTT assay. Compounds 10, 11, 12 and 14 possessed potent anticancer activity against various human cancer cell lines. The most potent indanone (10, IC(50)=2.2 microM), against MCF-7, that is, hormone-dependent breast cancer cell line, showed no toxicity to human erythrocytes even at higher concentrations (100 microg/ml, 258 microM). While, indanones 11, 12 and 14 showed toxicities to erythrocytes at higher concentrations.

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Year: 2008 PMID： 18586491 DOI： 10.1016/j.bmcl.2008.06.039

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

12 in total

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10. Isolation and characterization of gallic acid and methyl gallate from the seed coats of Givotia rottleriformis Griff. and their anti-proliferative effect on human epidermoid carcinoma A431 cells.

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Journal: Toxicol Rep Date: 2015-03-14

Gallic acid-based indanone derivatives as anticancer agents.

1. Synthesis of Functionalized Alkylidene Indanes and Indanones through Tandem Phosphine-Palladium Catalysis.

2. Insight into microtubule destabilization mechanism of 3,4,5-trimethoxyphenyl indanone derivatives using molecular dynamics simulation and conformational modes analysis.

3. Application of the McMurry coupling reaction in the synthesis of tri- and tetra-arylethylene analogues as potential cancer chemotherapeutic agents.

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8. Stimulating effect of a novel synthesized sulfonamido-based gallate ZXHA-TC on primary osteoblasts.

9. Investigation of the Key Pharmacological Activities of Ficus racemosa and Analysis of Its Major Bioactive Polyphenols by HPLC-DAD.

10. Isolation and characterization of gallic acid and methyl gallate from the seed coats of Givotia rottleriformis Griff. and their anti-proliferative effect on human epidermoid carcinoma A431 cells.