Literature DB >> 18586079

Innate immunity and aging.

Christian R Gomez1, Vanessa Nomellini, Douglas E Faunce, Elizabeth J Kovacs.   

Abstract

Advanced age is associated with defects in all of the cells of the innate immune system, including numbers, function, and early stages of activation. This review, presents the current state of the field on the impact of age on the innate immune system. The analysis of the literature suggests that a dysfunctional innate immune system is a contributing factor to aberrant outcomes after injury or infection and to the development of many of the diseases observed in the elderly. Gaining an understanding of the nature of the defects in innate immune cells may allow the development of therapeutic strategies aimed to restore innate immune function in aged individuals.

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Year:  2008        PMID： 18586079      PMCID： PMC2564282          DOI： 10.1016/j.exger.2008.05.016

Source DB:  PubMed          Journal:  Exp Gerontol        ISSN： 0531-5565            Impact factor:   4.032


  179 in total

Review 1.  Immunity to influenza: the challenges of protecting an aging population.

Authors:  Jacqueline M Katz; Julie Plowden; Mary Renshaw-Hoelscher; Xiuhua Lu; Terrence M Tumpey; Suryaprakash Sambhara
Journal:  Immunol Res       Date:  2004       Impact factor: 2.829

2.  Long-term retention of mature NK1.1+ NKT cells in the thymus.

Authors:  Stuart P Berzins; Finlay W McNab; Claerwen M Jones; Mark J Smyth; Dale I Godfrey
Journal:  J Immunol       Date:  2006-04-01       Impact factor: 5.422

Review 3.  Aging of the immune system as a prognostic factor for human longevity.

Authors:  Anis Larbi; Claudio Franceschi; Dawn Mazzatti; Rafael Solana; Anders Wikby; Graham Pawelec
Journal:  Physiology (Bethesda)       Date:  2008-04

4.  Different IL-8 production by T and NK lymphocytes in elderly subjects.

Authors:  E Mariani; L Pulsatelli; A Meneghetti; P Dolzani; I Mazzetti; S Neri; G Ravaglia; P Forti; A Facchini
Journal:  Mech Ageing Dev       Date:  2001-09-15       Impact factor: 5.432

Review 5.  B cells, E2A, and aging.

Authors:  Richard L Riley; Bonnie B Blomberg; Daniela Frasca
Journal:  Immunol Rev       Date:  2005-06       Impact factor: 12.988

6.  Protective roles of mast cells and mast cell-derived TNF in murine malaria.

Authors:  Takahisa Furuta; Takane Kikuchi; Yoichiro Iwakura; Naohiro Watanabe
Journal:  J Immunol       Date:  2006-09-01       Impact factor: 5.422

7.  Estradiol and progesterone treatments change the lipid profile in naturally menopausal rats from different age groups.

Authors:  K Moorthy; Umesh C S Yadav; Anil K Mantha; Sudha M Cowsik; D Sharma; S F Basir; N Z Baquer
Journal:  Biogerontology       Date:  2004       Impact factor: 4.277

8.  Age related variations of some polymorphonuclear leukocyte functions.

Authors:  T Fülöp; G Fóris; I Wórum; G Paragh; A Leövey
Journal:  Mech Ageing Dev       Date:  1985-01       Impact factor: 5.432

Review 9.  Eosinophils in the pathogenesis of allergic airways disease.

Authors:  S G Trivedi; C M Lloyd
Journal:  Cell Mol Life Sci       Date:  2007-05       Impact factor: 9.261

10.  Comparison of the effects of aging and IL-6 on the hepatic inflammatory response in two models of systemic injury: scald injury versus i.p. LPS administration.

Authors:  Christian R Gomez; Vanessa Nomellini; Horea Baila; Kiyoko Oshima; Elizabeth J Kovacs
Journal:  Shock       Date:  2009-02       Impact factor: 3.454
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  92 in total

Review 1.  Neutrophils in periodontal inflammation.

Authors:  David A Scott; Jennifer Krauss
Journal:  Front Oral Biol       Date:  2011-11-11

2.  The role of nutrition in enhancing immunity in aging.

Authors:  Munkyong Pae; Simin Nikbin Meydani; Dayong Wu
Journal:  Aging Dis       Date:  2011-09-30       Impact factor: 6.745

Review 3.  The ageing immune system: is it ever too old to become young again?

Authors:  Kenneth Dorshkind; Encarnacion Montecino-Rodriguez; Robert A J Signer
Journal:  Nat Rev Immunol       Date:  2009-01       Impact factor: 53.106

4.  Tumor-infiltrating lymphocyte grade in primary melanomas is independently associated with melanoma-specific survival in the population-based genes, environment and melanoma study.

Authors:  Nancy E Thomas; Klaus J Busam; Lynn From; Anne Kricker; Bruce K Armstrong; Hoda Anton-Culver; Stephen B Gruber; Richard P Gallagher; Roberto Zanetti; Stefano Rosso; Terence Dwyer; Alison Venn; Peter A Kanetsky; Pamela A Groben; Honglin Hao; Irene Orlow; Anne S Reiner; Li Luo; Susan Paine; David W Ollila; Homer Wilcox; Colin B Begg; Marianne Berwick
Journal:  J Clin Oncol       Date:  2013-10-14       Impact factor: 44.544

Review 5.  Vaccinomics and a new paradigm for the development of preventive vaccines against viral infections.

Authors:  Gregory A Poland; Inna G Ovsyannikova; Richard B Kennedy; Iana H Haralambieva; Robert M Jacobson
Journal:  OMICS       Date:  2011-07-06

Review 6.  Homeostatic migration and distribution of innate immune cells in primary and secondary lymphoid organs with ageing.

Authors:  J Nikolich-Žugich; J S Davies
Journal:  Clin Exp Immunol       Date:  2017-03       Impact factor: 4.330

7.  Age- and Sex-associated Differences in Phenotypic and Functional Characteristics of Peripheral Blood Lymphocytes in Chimpanzees (Pan troglodytes).

Authors:  Pramod N Nehete; Elizabeth R Magden; Bharti P Nehete; Lawrence E Williams; Christian R Abee; K Jagannadha Sastry
Journal:  J Am Assoc Lab Anim Sci       Date:  2017-09-01       Impact factor: 1.232

8.  Serum chitotriosidase, a putative marker of chronically activated macrophages, increases with normal aging.

Authors:  Rohit Ramanathan; Anita Kohli; María Clara Ingaramo; Alka Jain; Sean X Leng; Naresh M Punjabi; Jeremy D Walston; Neal S Fedarko
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2013-03-22       Impact factor: 6.053

9.  Neutrophils are immune cells preferentially targeted by retinoic acid in elderly subjects.

Authors:  Régine Minet-Quinard; M Chantal Farges; Emilie Thivat; Cécile Deleine; Gilles Mayot; Julius Brtko; Josep Ribalta; Brigitte Winklhofer-Roob; Edmond Rock; M Paule Vasson
Journal:  Immun Ageing       Date:  2010-08-20       Impact factor: 6.400

Review 10.  Immunotherapy of pediatric brain tumor patients should include an immunoprevention strategy: a medical hypothesis paper.

Authors:  Lara Driggers; Jian-Gang Zhang; Elizabeth W Newcomb; Lisheng Ge; Neil Hoa; Martin R Jadus
Journal:  J Neurooncol       Date:  2009-10-04       Impact factor: 4.130
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