Wynnie W M Lam1, W Y Au, Winnie C W Chu, S Tam, S Y Ha, D J Pennell. 1. Department of Diagnostic Radiology and Organ Imaging, Chinese University of Hong Kong, Prince of Wales Hospital, 30-32 Ngan Shing Street, Hong Kong SAR. wynnie@cuhk.edu.hk
Abstract
PURPOSE: To assess the feasibility of one-stop evaluation of iron load of myocardium, liver, and anterior pituitary gland in thalassemia patients. MATERIALS AND METHODS: Fifty thalassemia major patients underwent a breath-hold magnetic resonance imaging (MRI) sequence for assessment of T2* for liver and myocardium, a short axis cine trueFISP sequence covering base to apex to assess the ejection fraction of left ventricle, and a turbo spin echo T2-weighted sequence for the anterior pituitary gland. The MRI parameters were correlated with serum growth hormone, insulin growth factor-1 (IGF-1), insulin growth factor binding protein-3 (IGFBP-3), and endocrine failure. RESULTS: Ferritin was found to be associated with T2* liver (P < 0.005), T2SI (signal intensity) pituitary (P = 0.001), and T2 pituitary/fat (P = 0.001), but not with T2* heart. There was significant correlation of T2SI pituitary with IGF-1 and IGFBP-3. T2* liver (P < 0.001), T2* heart (P < 0.001), pituitary SI (P < 0.001) and pituitary/fat SI (P = 0.002) were also found to be significantly correlated with a history of hypogonadism. T2* heart was also found to be significantly correlated with IGF-1. CONCLUSION: A quick MRI protocol for assessment of T2* liver, T2* heart, and T2SI pituitary is technically feasible. This might form an objective basis to monitor the response to different organs to chelation therapy. (c) 2008 Wiley-Liss, Inc.
PURPOSE: To assess the feasibility of one-stop evaluation of iron load of myocardium, liver, and anterior pituitary gland in thalassemiapatients. MATERIALS AND METHODS: Fifty thalassemia major patients underwent a breath-hold magnetic resonance imaging (MRI) sequence for assessment of T2* for liver and myocardium, a short axis cine trueFISP sequence covering base to apex to assess the ejection fraction of left ventricle, and a turbo spin echo T2-weighted sequence for the anterior pituitary gland. The MRI parameters were correlated with serum growth hormone, insulin growth factor-1 (IGF-1), insulin growth factor binding protein-3 (IGFBP-3), and endocrine failure. RESULTS: Ferritin was found to be associated with T2* liver (P < 0.005), T2SI (signal intensity) pituitary (P = 0.001), and T2 pituitary/fat (P = 0.001), but not with T2* heart. There was significant correlation of T2SI pituitary with IGF-1 and IGFBP-3. T2* liver (P < 0.001), T2* heart (P < 0.001), pituitary SI (P < 0.001) and pituitary/fat SI (P = 0.002) were also found to be significantly correlated with a history of hypogonadism. T2* heart was also found to be significantly correlated with IGF-1. CONCLUSION: A quick MRI protocol for assessment of T2* liver, T2* heart, and T2SI pituitary is technically feasible. This might form an objective basis to monitor the response to different organs to chelation therapy. (c) 2008 Wiley-Liss, Inc.
Authors: Daniel Kim; Jens H Jensen; Ed X Wu; Li Feng; Wing-Yan Au; Jerry S Cheung; Shau-Yin Ha; Sujit S Sheth; Gary M Brittenham Journal: NMR Biomed Date: 2010-12-28 Impact factor: 4.044
Authors: M Beth McCarville; Claudia M Hillenbrand; Ralf B Loeffler; Matthew P Smeltzer; Ruitan Song; Chin-Shang Li; Jane S Hankins Journal: Pediatr Radiol Date: 2010-03-24
Authors: Hua Guo; Wing-Yan Au; Jerry S Cheung; Daniel Kim; Jens H Jensen; Pek-Lan Khong; Queenie Chan; Kevin C Chan; Christina Tosti; Haiying Tang; Truman R Brown; Wynnie W M Lam; Shau-Yin Ha; Gary M Brittenham; Ed X Wu Journal: J Magn Reson Imaging Date: 2009-08 Impact factor: 4.813