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Literature DB >> 18574461

Epigenetic biomarkers in psychiatric disorders.

Abstract

The discovery of biomarkers in psychiatric disorders may help in the diagnosis, prevention and treatment of patients with these disorders. Here, I discuss the potential role of epigenetic biomarkers, that is, epigenetically altered genes and/or expression patterns of proteins or metabolites, in psychiatric disorders. Before epigenetic biomarkers can be clinically applied in these disorders, several issues need to be addressed. These include establishing a connection between biomarkers and the disease process; determining the predictive quality of the biomarkers; determining the effects of disease heterogeneity on the biomarkers; and identifying sample sources for the biomarkers that are easily accessible for testing.

Entities: Disease Species

Mesh：

Substances：
Biomarkers

Year: 2008 PMID： 18574461 PMCID： PMC2597243 DOI： 10.1038/bjp.2008.254

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

10 in total

1. Metabolic profiling of plasma from discordant schizophrenia twins: correlation between lipid signals and global functioning in female schizophrenia patients.

Authors: Tsz M Tsang; Jeffrey T-J Huang; Elaine Holmes; Sabine Bahn
Journal: J Proteome Res Date: 2006-04 Impact factor: 4.466

2. Revisiting the methylation hypothesis for the psychoses.

Authors: Jacob Peedicayil; Prasanna Kumar T Subbanna
Journal: Med Hypotheses Date: 2006-10-02 Impact factor: 1.538

Review 3. The dynamic epigenome and its implications in toxicology.

Authors: Moshe Szyf
Journal: Toxicol Sci Date: 2007-08-03 Impact factor: 4.849

4. Evaluating the comparability of gene expression in blood and brain.

Authors: Patrick F Sullivan; Cheng Fan; Charles M Perou
Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2006-04-05 Impact factor: 3.568

5. Reelin is a ligand for lipoprotein receptors.

Authors: G D'Arcangelo; R Homayouni; L Keshvara; D S Rice; M Sheldon; T Curran
Journal: Neuron Date: 1999-10 Impact factor: 17.173

Review 6. Reelin glycoprotein: structure, biology and roles in health and disease.

Authors: S H Fatemi
Journal: Mol Psychiatry Date: 2005-03 Impact factor: 15.992

Review 7. Epigenetics: relations to disease and laboratory findings.

Authors: Masato Maekawa; Yoshihisa Watanabe
Journal: Curr Med Chem Date: 2007 Impact factor: 4.530

Review 8. The utility of biomarker discovery approaches for the detection of disease mechanisms in psychiatric disorders.

Authors: E Schwarz; S Bahn
Journal: Br J Pharmacol Date: 2008-01-14 Impact factor: 8.739

Review 9. The role of epigenetics in mental disorders.

Authors: Jacob Peedicayil
Journal: Indian J Med Res Date: 2007-08 Impact factor: 2.375

10. Decreased expression of reelin receptor VLDLR in peripheral lymphocytes of drug-naive schizophrenic patients.

Authors: Katsuaki Suzuki; Kazuhiko Nakamura; Yasuhide Iwata; Yoshimoto Sekine; Masayoshi Kawai; Genichi Sugihara; Kenji J Tsuchiya; Shiro Suda; Hideo Matsuzaki; Nori Takei; Kenji Hashimoto; Norio Mori
Journal: Schizophr Res Date: 2007-10-23 Impact factor: 4.939

10 in total

6 in total

Review 1. Annual Research Review: Epigenetic mechanisms and environmental shaping of the brain during sensitive periods of development.

Authors: Tania L Roth; J David Sweatt
Journal: J Child Psychol Psychiatry Date: 2011-04 Impact factor: 8.982