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Literature DB >> 18573660

Molecular recognition of a DNA:RNA hybrid: sub-nanomolar binding by a neomycin-methidium conjugate.

Nicholas N Shaw¹, Hongjuan Xi, Dev P Arya.

Abstract

A novel neomycin-methidium conjugate was synthesized. The covalent linkage of the aminoglycoside to an intercalator, a derivative of ethidium bromide, results in a new conjugate capable of selective recognition of the DNA:RNA hybrid duplex. Spectroscopic methods: UV, CD, fluorescence, and calorimetric techniques: DSC and ITC were used to characterize the sub-nanomolar binding displayed by the conjugate for the DNA:RNA hybrid duplex, poly(dA):poly(rU).

Entities: Chemical Disease

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Year: 2008 PMID： 18573660 DOI： 10.1016/j.bmcl.2008.05.090

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

33 in total

1. Click dimers to target HIV TAR RNA conformation.

Authors: Sunil Kumar; Patrick Kellish; W Edward Robinson; Deyun Wang; Daniel H Appella; Dev P Arya
Journal: Biochemistry Date: 2012-03-09 Impact factor: 3.162

Review 2. New approaches toward recognition of nucleic acid triple helices.

Authors: Dev P Arya
Journal: Acc Chem Res Date: 2010-11-12 Impact factor: 22.384

3. Probing the molecular recognition of a DNA.RNA hybrid duplex.

Authors: Richard T Wheelhouse; Nichola C Garbett; Niklaas J Buurma; Jonathan B Chaires
Journal: Angew Chem Int Ed Engl Date: 2010-04-19 Impact factor: 15.336

4. Recognition of HIV-TAR RNA using neomycin-benzimidazole conjugates.

Authors: Nihar Ranjan; Sunil Kumar; Derrick Watkins; Deyun Wang; Daniel H Appella; Dev P Arya
Journal: Bioorg Med Chem Lett Date: 2013-08-14 Impact factor: 2.823

5. Utilization of chromic polydiacetylene assemblies as a platform to probe specific binding between drug and RNA.

Authors: Anothai Kamphan; Changjun Gong; Krishnagopal Maiti; Souvik Sur; Rakchart Traiphol; Dev P Arya
Journal: RSC Adv Date: 2017-08-24 Impact factor: 3.361

Review 6. Comprehensive review of chemical strategies for the preparation of new aminoglycosides and their biological activities.

Authors: Nishad Thamban Chandrika; Sylvie Garneau-Tsodikova
Journal: Chem Soc Rev Date: 2018-02-19 Impact factor: 54.564

Molecular recognition of a DNA:RNA hybrid: sub-nanomolar binding by a neomycin-methidium conjugate.

1. Click dimers to target HIV TAR RNA conformation.

Review 2. New approaches toward recognition of nucleic acid triple helices.

3. Probing the molecular recognition of a DNA.RNA hybrid duplex.

4. Recognition of HIV-TAR RNA using neomycin-benzimidazole conjugates.

5. Utilization of chromic polydiacetylene assemblies as a platform to probe specific binding between drug and RNA.

Review 6. Comprehensive review of chemical strategies for the preparation of new aminoglycosides and their biological activities.

7. Thermodynamics of nucleic acid "shape readout" by an aminosugar.

8. Linker dependent intercalation of bisbenzimidazole-aminosugars in an RNA duplex; selectivity in RNA vs. DNA binding.

9. Drug binding to DNA x RNA hybrid structures.

10. Shape readout of AT-rich DNA by carbohydrates.