Literature DB >> 18573329

Increase of Dkk-3 blood plasma levels in the elderly.

Christoph Zenzmaier1, Lilian Sklepos, Peter Berger.   

Abstract

Gene expression of the secreted glycoprotein Dkk-3 is upregulated during cellular senescence in prostate basal epithelial cells and altered in age-related disorders of the human prostate. In order to quantify the influence of such age- and disease-related changes of Dkk-3 levels in body fluids, we established a highly specific and sensitive indirect IEMA. Results revealed a significant increase of Dkk-3 blood plasma levels in the elderly (1.17+/-0.36 vs. 1.61+/-0.61 nmol/L) indicating a non-negligible physiological role and its use as a marker for senescence not only in vitro but also in vivo.

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Year:  2008        PMID： 18573329     DOI： 10.1016/j.exger.2008.05.012

Source DB:  PubMed          Journal:  Exp Gerontol        ISSN： 0531-5565            Impact factor:   4.032


  8 in total

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Journal:  Transl Res       Date:  2020-03-10       Impact factor: 7.012

2.  Dkk-3 is elevated in CSF and plasma of Alzheimer's disease patients.

Authors:  Christoph Zenzmaier; Josef Marksteiner; Andreas Kiefer; Peter Berger; Christian Humpel
Journal:  J Neurochem       Date:  2009-05-11       Impact factor: 5.372

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4.  Elevated levels of Dickkopf-related protein 3 in seminal plasma of prostate cancer patients.

Authors:  Christoph Zenzmaier; Martin Heitz; Helmut Klocker; Marion Buck; Robert A Gardiner; Peter Berger
Journal:  J Transl Med       Date:  2011-11-10       Impact factor: 5.531

5.  The emerging plasma biomarker Dickkopf-3 (DKK3) and its association with renal and cardiovascular disease in the general population.

Authors:  Arnold Piek; Leonie Smit; Navin Suthahar; Stephan J L Bakker; Rudolf A de Boer; Herman H W Silljé
Journal:  Sci Rep       Date:  2021-04-21       Impact factor: 4.379

6.  Dickkopf-related protein 3 promotes pathogenic stromal remodeling in benign prostatic hyperplasia and prostate cancer.

Authors:  Christoph Zenzmaier; Natalie Sampson; Eugen Plas; Peter Berger
Journal:  Prostate       Date:  2013-06-14       Impact factor: 4.104

7.  Dkk3 dependent transcriptional regulation controls age related skeletal muscle atrophy.

Authors:  Jie Yin; Lele Yang; Yangli Xie; Yan Liu; Sheng Li; Wenjun Yang; Bo Xu; Hongbin Ji; Lianghua Ding; Kun Wang; Gang Li; Lin Chen; Ping Hu
Journal:  Nat Commun       Date:  2018-05-01       Impact factor: 14.919

8.  A combined bioinformatics, experimental and clinical approach to identify novel cardiac-specific heart failure biomarkers: is Dickkopf-3 (DKK3) a possible candidate?

Authors:  Arnold Piek; Navin Suthahar; Adriaan A Voors; Rudolf A de Boer; Herman H W Silljé
Journal:  Eur J Heart Fail       Date:  2020-09-22       Impact factor: 15.534
  8 in total

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