| Literature DB >> 18571459 |
Walter de Vries1, Ben Berkhout.
Abstract
RNA silencing or RNAi interference (RNAi) serves as an innate antiviral mechanism in plants, fungi and animals. Human viruses, like plant viruses, encode suppressor proteins or RNAs that block or modulate the RNAi pathway. This review summarizes the mechanisms by which pathogenic human viruses affect the RNAi pathway. Furthermore, some applications of the viral RNAi suppressor functions and the consequences for antiviral therapeutic strategies that are based on RNAi are discussed.Entities:
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Year: 2008 PMID： 18571459 DOI： 10.1016/j.biocel.2008.04.015
Source DB: PubMed Journal: Int J Biochem Cell Biol ISSN： 1357-2725 Impact factor: 5.085