OBJECTIVE: To test the hypothesis that early knee and hand osteoarthritis (OA) development is characterized by detectable changes in serum proteins relevant to inflammation, cell growth, activation, and metabolism several years before OA becomes radiographically evident. METHODS: Using microarray platforms that simultaneously test 169 proteins relevant to inflammation, cell growth, activation and metabolism, we conducted a case-control study nested within the Baltimore Longitudinal Study of Aging (BLSA). Subjects included 22 incident cases of OA and 66 age-, sex- and body mass index (BMI)-matched controls. Serum samples tested were obtained at the time of radiographic classification as either case or control, and up to 10 years earlier at a time when all participants were free of radiographic OA. Proteins with mean signal intensities fourfold higher than background were compared between cases and controls using multivariate techniques. RESULTS: Sixteen proteins were different between OA cases compared to controls. Four of these proteins [matrix metalloproteinase (MMP)-7, interleukin (IL)-15, plasminogen activator inhibitor (PAI)-1 and soluble vascular adhesion protein (sVAP)-1] were already different in samples obtained 10 years before radiographic classification and remained different at the time of diagnosis. Six additional proteins were only associated with subsequent OA development and not with established OA. CONCLUSIONS: Changes in serum proteins implicated in matrix degradation, cell activation, inflammation and bone collagen degradation products accompany early OA development and can precede radiographic detection by several years.
OBJECTIVE: To test the hypothesis that early knee and hand osteoarthritis (OA) development is characterized by detectable changes in serum proteins relevant to inflammation, cell growth, activation, and metabolism several years before OA becomes radiographically evident. METHODS: Using microarray platforms that simultaneously test 169 proteins relevant to inflammation, cell growth, activation and metabolism, we conducted a case-control study nested within the Baltimore Longitudinal Study of Aging (BLSA). Subjects included 22 incident cases of OA and 66 age-, sex- and body mass index (BMI)-matched controls. Serum samples tested were obtained at the time of radiographic classification as either case or control, and up to 10 years earlier at a time when all participants were free of radiographic OA. Proteins with mean signal intensities fourfold higher than background were compared between cases and controls using multivariate techniques. RESULTS: Sixteen proteins were different between OA cases compared to controls. Four of these proteins [matrix metalloproteinase (MMP)-7, interleukin (IL)-15, plasminogen activator inhibitor (PAI)-1 and soluble vascular adhesion protein (sVAP)-1] were already different in samples obtained 10 years before radiographic classification and remained different at the time of diagnosis. Six additional proteins were only associated with subsequent OA development and not with established OA. CONCLUSIONS: Changes in serum proteins implicated in matrix degradation, cell activation, inflammation and bone collagen degradation products accompany early OA development and can precede radiographic detection by several years.
Authors: Bo Baslund; Niels Tvede; Bente Danneskiold-Samsoe; Per Larsson; Gabriel Panayi; Joergen Petersen; Lars J Petersen; Frank J M Beurskens; Janine Schuurman; Jan G J van de Winkel; Paul W H I Parren; J Alastair Gracie; Sarah Jongbloed; Foo Y Liew; Iain B McInnes Journal: Arthritis Rheum Date: 2005-09
Authors: I Meulenbelt; M Kloppenburg; H M Kroon; J J Houwing-Duistermaat; P Garnero; M-P Hellio-Le Graverand; J DeGroot; P E Slagboom Journal: Osteoarthritis Cartilage Date: 2006-10-17 Impact factor: 6.576
Authors: Patrick Garnero; Bernard Mazières; Alice Guéguen; Michel Abbal; Laurent Berdah; Michel Lequesne; Minh Nguyen; Jean-Pierre Salles; Eric Vignon; Maxime Dougados Journal: J Rheumatol Date: 2005-04 Impact factor: 4.666
Authors: C G Peterfy; A Guermazi; S Zaim; P F J Tirman; Y Miaux; D White; M Kothari; Y Lu; K Fye; S Zhao; H K Genant Journal: Osteoarthritis Cartilage Date: 2004-03 Impact factor: 6.576
Authors: Weiping Shao; Zhimin Zhou; Isabelle Laroche; Hong Lu; Qiuling Zong; Dhavalkumar D. Patel; Stephen Kingsmore; Steven P. Piccoli Journal: J Biomed Biotechnol Date: 2003
Authors: B Shoukri; J C Prieto; A Ruellas; M Yatabe; J Sugai; M Styner; H Zhu; C Huang; B Paniagua; S Aronovich; L Ashman; E Benavides; P de Dumast; N T Ribera; C Mirabel; L Michoud; Z Allohaibi; M Ioshida; L Bittencourt; L Fattori; L R Gomes; L Cevidanes Journal: J Dent Res Date: 2019-07-24 Impact factor: 6.116