| Literature DB >> 18571406 |
Masaaki Ozawa1, Kazuki Honda, Izumi Nakai, Akio Kishida, Ayumi Ohsaki.
Abstract
An indole alkaloid (hypaphorine (1)) was isolated from Brazilian medicinal plant, Erythrina velutina (Leguminosae). This compound was investigated for sleep promoting effects in mice, and the results showed that it significantly increased non-rapid eye movement (NREM) sleep time during the first hour after its administration. The NREM sleep time was enhanced by 33% in the experimental mice when compared to that of the controls. This study therefore confirmed its sleep promoting property.Entities:
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Year: 2008 PMID： 18571406 DOI： 10.1016/j.bmcl.2008.06.002
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823