OBJECTIVE: To assess fecundity of infertile women after surgical correction of uterine septum. DESIGN: Prospective controlled trial. SETTING: Three academic infertility clinics. PATIENT(S): Forty-four women affected by septate uterus and otherwise unexplained infertility represented the study group (group A), and 132 women with unexplained infertility were enrolled as control subjects (group B). INTERVENTION(S): Hysteroscopic metroplasty was performed in group A, and group B was managed expectantly. All women were followed-up for 1 year without any other intervention. MAIN OUTCOME MEASURE(S): Fecundity rate was calculated as the number of pregnancies per 100 person-months. RESULT(S): Pregnancy rate (38.6% vs. 20.4%) and live birth rate (34.1% and 18.9%) were significantly higher in group A than in group B. The survival analysis showed that the probability of a pregnancy in the twelve-months follow up was significantly higher in patients who had undergone metroplasty than in women with unexplained infertility. The corresponding fecundity (10-week pregnancy) rates were 4.27 and 1.92 person-months in women who had undergone metroplasty and in women with unexplained infertility, respectively. CONCLUSION(S): Hysteroscopic resection of the septum improves fecundity of women with septate uterus and otherwise unexplained infertility. Patients with septate uterus and no other cause of sterility have a significantly higher probability of conceiving after removal of the septum than patients affected by idiopathic sterility.
RCT Entities:
OBJECTIVE: To assess fecundity of infertile women after surgical correction of uterine septum. DESIGN: Prospective controlled trial. SETTING: Three academic infertility clinics. PATIENT(S): Forty-four women affected by septate uterus and otherwise unexplained infertility represented the study group (group A), and 132 women with unexplained infertility were enrolled as control subjects (group B). INTERVENTION(S): Hysteroscopic metroplasty was performed in group A, and group B was managed expectantly. All women were followed-up for 1 year without any other intervention. MAIN OUTCOME MEASURE(S): Fecundity rate was calculated as the number of pregnancies per 100 person-months. RESULT(S): Pregnancy rate (38.6% vs. 20.4%) and live birth rate (34.1% and 18.9%) were significantly higher in group A than in group B. The survival analysis showed that the probability of a pregnancy in the twelve-months follow up was significantly higher in patients who had undergone metroplasty than in women with unexplained infertility. The corresponding fecundity (10-week pregnancy) rates were 4.27 and 1.92 person-months in women who had undergone metroplasty and in women with unexplained infertility, respectively. CONCLUSION(S): Hysteroscopic resection of the septum improves fecundity of women with septate uterus and otherwise unexplained infertility. Patients with septate uterus and no other cause of sterility have a significantly higher probability of conceiving after removal of the septum than patients affected by idiopathic sterility.
Authors: Marco Noventa; Giulia Spagnol; Matteo Marchetti; Carlo Saccardi; Giulio Bonaldo; Antonio Simone Laganà; Francesco Cavallin; Alessandra Andrisani; Guido Ambrosini; Salvatore Giovanni Vitale; Luis Alonso Pacheco; Sergio Haimovich; Attilio Di Spiezio Sardo; Jose Carugno; Marco Scioscia; Simone Garzon; Stefano Bettocchi; Giovanni Buzzaccarini; Roberto Tozzi; Amerigo Vitagliano Journal: J Clin Med Date: 2022-06-08 Impact factor: 4.964
Authors: Kazem Nouri; Johannes Ott; Johannes C Huber; Eva-Maria Fischer; Lucija Stögbauer; Clemens B Tempfer Journal: Reprod Biol Endocrinol Date: 2010-05-21 Impact factor: 5.211
Authors: Jan Bosteels; Steffi van Wessel; Steven Weyers; Frank J Broekmans; Thomas M D'Hooghe; M Y Bongers; Ben Willem J Mol Journal: Cochrane Database Syst Rev Date: 2018-12-05
Authors: Grigoris F Grimbizis; Stephan Gordts; Attilio Di Spiezio Sardo; Sara Brucker; Carlo De Angelis; Marco Gergolet; Tin-Chiu Li; Vasilios Tanos; Hans Brölmann; Luca Gianaroli; Rudi Campo Journal: Hum Reprod Date: 2013-06-14 Impact factor: 6.918
Authors: Grigoris F Grimbizis; Stephan Gordts; Attilio Di Spiezio Sardo; Sara Brucker; Carlo De Angelis; Marco Gergolet; Tin-Chiu Li; Vasilios Tanos; Hans Brölmann; Luca Gianaroli; Rudi Campo Journal: Gynecol Surg Date: 2013-06-13