Literature DB >> 18570211

Antitumor activity of extracts and compounds from the rhizomes of Veratrum dahuricum.

Jian Tang1, Hui-Liang Li, Yun-Heng Shen, Hui-Zi Jin, Shi-Kai Yan, Run-Hui Liu, Wei-Dong Zhang.   

Abstract

The antitumor activity of six extracts (ethanol extract, petroleum ether fraction, CHCl(3) fraction, ethyl acetate fraction, n-butanol fraction and total alkaloids) from the rhizomes of Veratrum dahuricum, and six compounds (veratramine (1), jervine (2), germine (3), veramitaline (4), veratrosine (5) and cyclopamine (6)) from the ethanol extract were investigated in vitro. The 12 samples exhibited cytotoxic activity against human tumor cell lines A549, PANC-1, SW1990 and NCI-H249. Among these samples, CHCl(3) fraction, the total alkaloids, compounds 1 and 6 showed higher inhibitory activity, compound 3 selectively exhibited significant cytotoxicity to SW1990 and NCI-H249.

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Year:  2008        PMID： 18570211     DOI： 10.1002/ptr.2463

Source DB:  PubMed          Journal:  Phytother Res        ISSN： 0951-418X            Impact factor:   5.878


  9 in total

1.  Pharmacokinetics of Veratramine and Jervine from Alcohol Extracts of Radix Veratri.

Authors:  Song Wang; Jiali Cui; Gaoqiong Zhao; Hongbin Liu; Jingkun Wang
Journal:  Comput Math Methods Med       Date:  2022-06-23       Impact factor: 2.809

Review 2.  Chemistry and bioactivities of natural steroidal alkaloids.

Authors:  Mei-Ling Xiang; Bin-Yuan Hu; Zi-Heng Qi; Xiao-Na Wang; Tian-Zhen Xie; Zhao-Jie Wang; Dan-Yu Ma; Qi Zeng; Xiao-Dong Luo
Journal:  Nat Prod Bioprospect       Date:  2022-06-15

3.  Gender-Dependent Pharmacokinetics of Veratramine in Rats: In Vivo and In Vitro Evidence.

Authors:  Chunming Lyu; Yufeng Zhang; Wenbin Zhou; Shen Zhang; Fang Kou; Hai Wei; Ning Zhang; Zhong Zuo
Journal:  AAPS J       Date:  2016-01-20       Impact factor: 4.009

4.  Investigations on inhibitors of hedgehog signal pathway: a quantitative structure-activity relationship study.

Authors:  Ruixin Zhu; Qi Liu; Jian Tang; Huiliang Li; Zhiwei Cao
Journal:  Int J Mol Sci       Date:  2011-05-11       Impact factor: 5.923

5.  Prosapogenin A induces apoptosis in human cancer cells in vitro via inhibition of the STAT3 signaling pathway and glycolysis.

Authors:  Tian-Xiao Wang; Zhong-Qing Zhang; Yue Cong; Xiao-Yan Shi; Ying-Hua Liu; Fang-Li Zhao
Journal:  Oncol Lett       Date:  2013-09-04       Impact factor: 2.967

6.  UPLC-MS/MS Method for the Simultaneous Quantification of Eight Compounds in Rat Plasma and Its Application to a Pharmacokinetic Study after Oral Administration of Veratrum (Veratrum nigrum L.) Extract.

Authors:  Yuqi Fan; Lulu Zhao; Xuhua Huang; Jiayuan Shen; Wei Wang; Xiaohua Jia; Mengyuan Gao; Huizi Ouyang; Yanxu Chang; Jun He
Journal:  Biomed Res Int       Date:  2020-10-19       Impact factor: 3.411

7.  Veratri Nigri Rhizoma et Radix (Veratrum nigrum L.) and Its Constituent Jervine Prevent Adipogenesis via Activation of the LKB1-AMPKα-ACC Axis In Vivo and In Vitro.

Authors:  Jinbong Park; Yong-Deok Jeon; Hye-Lin Kim; Dae-Seung Kim; Yo-Han Han; Yunu Jung; Dong-Hyun Youn; JongWook Kang; Daeyeon Yoon; Mi-Young Jeong; Jong-Hyun Lee; Seung-Heon Hong; Junhee Lee; Jae-Young Um
Journal:  Evid Based Complement Alternat Med       Date:  2016-04-06       Impact factor: 2.629

Review 8.  Therapeutic value of steroidal alkaloids in cancer: Current trends and future perspectives.

Authors:  Prasanta Dey; Amit Kundu; Hirak Jyoti Chakraborty; Babli Kar; Wahn Soo Choi; Byung Mu Lee; Tejendra Bhakta; Atanas G Atanasov; Hyung Sik Kim
Journal:  Int J Cancer       Date:  2019-01-21       Impact factor: 7.396

9.  Veratramine suppresses human HepG2 liver cancer cell growth in vitro and in vivo by inducing autophagic cell death.

Authors:  Linlin Yin; Yonghui Xia; Ping Xu; Wenli Zheng; Yuanyuan Gao; Faqin Xie; Zhaoning Ji
Journal:  Oncol Rep       Date:  2020-05-25       Impact factor: 3.906
  9 in total

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