Literature DB >> 18568158

Small molecule inhibition of microbial natural product biosynthesis-an emerging antibiotic strategy.

Justin S Cisar1, Derek S Tan.   

Abstract

A variety of natural products modulate critical biological processes in the microorganisms that produce them. Thus, inhibition of the corresponding natural product biosynthesis pathways represents a promising avenue to develop novel antibiotics. In this tutorial review, we describe several recent examples of designed small molecule inhibitors of microbial natural product biosynthesis and their use in evaluating this emerging antibiotic strategy.

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Year:  2008        PMID： 18568158      PMCID： PMC2587208          DOI： 10.1039/b702780j

Source DB:  PubMed          Journal:  Chem Soc Rev        ISSN： 0306-0012            Impact factor:   54.564


  54 in total

Review 1.  Assembly of aryl-capped siderophores by modular peptide synthetases and polyketide synthases.

Authors:  L E Quadri
Journal:  Mol Microbiol       Date:  2000-07       Impact factor: 3.501

Review 2.  Genetics and assembly line enzymology of siderophore biosynthesis in bacteria.

Authors:  Jorge H Crosa; Christopher T Walsh
Journal:  Microbiol Mol Biol Rev       Date:  2002-06       Impact factor: 11.056

3.  The salicylate-derived mycobactin siderophores of Mycobacterium tuberculosis are essential for growth in macrophages.

Authors:  J J De Voss; K Rutter; B G Schroeder; H Su; Y Zhu; C E Barry
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-01       Impact factor: 11.205

Review 4.  Natural products as sources of new drugs over the period 1981-2002.

Authors:  David J Newman; Gordon M Cragg; Kenneth M Snader
Journal:  J Nat Prod       Date:  2003-07       Impact factor: 4.050

5.  The EntF and EntE adenylation domains of Escherichia coli enterobactin synthetase: sequestration and selectivity in acyl-AMP transfers to thiolation domain cosubstrates.

Authors:  D E Ehmann; C A Shaw-Reid; H C Losey; C T Walsh
Journal:  Proc Natl Acad Sci U S A       Date:  2000-03-14       Impact factor: 11.205

6.  Interference with Pseudomonas quinolone signal synthesis inhibits virulence factor expression by Pseudomonas aeruginosa.

Authors:  M W Calfee; J P Coleman; E C Pesci
Journal:  Proc Natl Acad Sci U S A       Date:  2001-09-25       Impact factor: 11.205

Review 7.  Iron metabolism in pathogenic bacteria.

Authors:  C Ratledge; L G Dover
Journal:  Annu Rev Microbiol       Date:  2000       Impact factor: 15.500

8.  Structural basis and specificity of acyl-homoserine lactone signal production in bacterial quorum sensing.

Authors:  William T Watson; Timothy D Minogue; Dale L Val; Susanne Beck von Bodman; Mair E A Churchill
Journal:  Mol Cell       Date:  2002-03       Impact factor: 17.970

9.  Crystal structure of DhbE, an archetype for aryl acid activating domains of modular nonribosomal peptide synthetases.

Authors:  Jurgen J May; Nadine Kessler; Mohamed A Marahiel; Milton T Stubbs
Journal:  Proc Natl Acad Sci U S A       Date:  2002-09-09       Impact factor: 11.205

10.  Pseudomonas aeruginosa PqsA is an anthranilate-coenzyme A ligase.

Authors:  James P Coleman; L Lynn Hudson; Susan L McKnight; John M Farrow; M Worth Calfee; Claire A Lindsey; Everett C Pesci
Journal:  J Bacteriol       Date:  2007-12-14       Impact factor: 3.490
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  11 in total

1.  Ironing out a new siderophore synthesis strategy.

Authors:  Andrew M Gulick
Journal:  Nat Chem Biol       Date:  2009-03       Impact factor: 15.040

2.  Active site-directed proteomic probes for adenylation domains in nonribosomal peptide synthetases.

Authors:  Sho Konno; Fumihiro Ishikawa; Takehiro Suzuki; Naoshi Dohmae; Michael D Burkart; Hideaki Kakeya
Journal:  Chem Commun (Camb)       Date:  2015-02-11       Impact factor: 6.222

3.  Stable analogues of OSB-AMP: potent inhibitors of MenE, the o-succinylbenzoate-CoA synthetase from bacterial menaquinone biosynthesis.

Authors:  Xuequan Lu; Rong Zhou; Indrajeet Sharma; Xiaokai Li; Gyanendra Kumar; Subramanyam Swaminathan; Peter J Tonge; Derek S Tan
Journal:  Chembiochem       Date:  2011-11-23       Impact factor: 3.164

4.  The antibiotic CJ-15,801 is an antimetabolite that hijacks and then inhibits CoA biosynthesis.

Authors:  Renier van der Westhuyzen; Justin C Hammons; Jordan L Meier; Samira Dahesh; Wessel J A Moolman; Stephen C Pelly; Victor Nizet; Michael D Burkart; Erick Strauss
Journal:  Chem Biol       Date:  2012-05-25

5.  Role for dithiolopyrrolones in disrupting bacterial metal homeostasis.

Authors:  Andrew N Chan; Anthony L Shiver; Walter J Wever; Sayyeda Zeenat A Razvi; Matthew F Traxler; Bo Li
Journal:  Proc Natl Acad Sci U S A       Date:  2017-02-16       Impact factor: 11.205

6.  Design, synthesis, and biological evaluation of α-hydroxyacyl-AMS inhibitors of amino acid adenylation enzymes.

Authors:  Tony D Davis; Poornima Mohandas; Maria I Chiriac; Glennon V Bythrow; Luis E N Quadri; Derek S Tan
Journal:  Bioorg Med Chem Lett       Date:  2016-09-16       Impact factor: 2.823

7.  An orthogonal active site identification system (OASIS) for proteomic profiling of natural product biosynthesis.

Authors:  Jordan L Meier; Sherry Niessen; Heather S Hoover; Timothy L Foley; Benjamin F Cravatt; Michael D Burkart
Journal:  ACS Chem Biol       Date:  2009-11-20       Impact factor: 5.100

8.  Mechanism-based inhibitors of MenE, an acyl-CoA synthetase involved in bacterial menaquinone biosynthesis.

Authors:  Xuequan Lu; Huaning Zhang; Peter J Tonge; Derek S Tan
Journal:  Bioorg Med Chem Lett       Date:  2008-08-12       Impact factor: 2.823

9.  Designed semisynthetic protein inhibitors of Ub/Ubl E1 activating enzymes.

Authors:  Xuequan Lu; Shaun K Olsen; Allan D Capili; Justin S Cisar; Christopher D Lima; Derek S Tan
Journal:  J Am Chem Soc       Date:  2010-02-17       Impact factor: 15.419

10.  Molecular characterization of an adaptive response to alkylating agents in the opportunistic pathogen Aspergillus fumigatus.

Authors:  Karen A O'Hanlon; Geoffrey P Margison; Amy Hatch; David A Fitzpatrick; Rebecca A Owens; Sean Doyle; Gary W Jones
Journal:  Nucleic Acids Res       Date:  2012-06-04       Impact factor: 16.971
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