Literature DB >> 18568156

Chemical technologies for probing embryonic development.

Ilya A Shestopalov1, James K Chen.   

Abstract

Embryogenesis is a remarkable program of cell proliferation, migration, and differentiation that transforms a single fertilized egg into a complex multicellular organism. Understanding this process at the molecular and systems levels will require an interdisciplinary approach, including the concepts and technologies of chemical biology. This tutorial review provides an overview of chemical tools that have been used in developmental biology research, focusing on methods that enable spatiotemporal control of gene function and the visualization of embryonic patterning. Limitations of current approaches and future challenges are also discussed.

Mesh：

Year:  2008        PMID： 18568156      PMCID： PMC2531163          DOI： 10.1039/b703023c

Source DB:  PubMed          Journal:  Chem Soc Rev        ISSN： 0306-0012            Impact factor:   54.564


  60 in total

1.  Photoactivated gene expression for cell fate mapping and cell manipulation.

Authors:  J Minden; R Namba; J Mergliano; S Cambridge
Journal:  Sci STKE       Date:  2000-12-12

2.  A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells.

Authors:  Xu Wu; Sheng Ding; Qiang Ding; Nathanael S Gray; Peter G Schultz
Journal:  J Am Chem Soc       Date:  2002-12-11       Impact factor: 15.419

3.  Chemical-inducible, ecdysone receptor-based gene expression system for plants.

Authors:  Malla Padidam; Michael Gore; D Lily Lu; Olga Smirnova
Journal:  Transgenic Res       Date:  2003-02       Impact factor: 2.788

4.  A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish.

Authors:  Andrea Geling; Harald Steiner; Michael Willem; Laure Bally-Cuif; Christian Haass
Journal:  EMBO Rep       Date:  2002-07       Impact factor: 8.807

Review 5.  GAL4 system in Drosophila: a fly geneticist's Swiss army knife.

Authors:  Joseph B Duffy
Journal:  Genesis       Date:  2002 Sep-Oct       Impact factor: 2.487

6.  Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened.

Authors:  James K Chen; Jussi Taipale; Michael K Cooper; Philip A Beachy
Journal:  Genes Dev       Date:  2002-11-01       Impact factor: 11.361

7.  Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila.

Authors:  Craig A Micchelli; William P Esler; W Taylor Kimberly; Christine Jack; Oksana Berezovska; Anna Kornilova; Bradley T Hyman; Norbert Perrimon; Michael S Wolfe
Journal:  FASEB J       Date:  2002-11-01       Impact factor: 5.191

8.  Caged Q-rhodamine dextran: a new photoactivated fluorescent tracer.

Authors:  K R Gee; E S Weinberg; D J Kozlowski
Journal:  Bioorg Med Chem Lett       Date:  2001-08-20       Impact factor: 2.823

9.  Small molecule modulation of Smoothened activity.

Authors:  James K Chen; Jussi Taipale; Keith E Young; Tapan Maiti; Philip A Beachy
Journal:  Proc Natl Acad Sci U S A       Date:  2002-10-21       Impact factor: 11.205

10.  Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542.

Authors:  N J Laping; E Grygielko; A Mathur; S Butter; J Bomberger; C Tweed; W Martin; J Fornwald; R Lehr; J Harling; L Gaster; J F Callahan; B A Olson
Journal:  Mol Pharmacol       Date:  2002-07       Impact factor: 4.436
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  7 in total

Review 1.  Oligonucleotide-based tools for studying zebrafish development.

Authors:  Ilya A Shestopalov; James K Chen
Journal:  Zebrafish       Date:  2010-03       Impact factor: 1.985

2.  Spatiotemporal control of embryonic gene expression using caged morpholinos.

Authors:  Ilya A Shestopalov; James K Chen
Journal:  Methods Cell Biol       Date:  2011       Impact factor: 1.441

3.  Small Molecule Control of Morpholino Antisense Oligonucleotide Function through Staudinger Reduction.

Authors:  Kristie Darrah; Joshua Wesalo; Bradley Lukasak; Michael Tsang; James K Chen; Alexander Deiters
Journal:  J Am Chem Soc       Date:  2021-10-27       Impact factor: 16.383

Review 4.  Novel synthetic biology approaches for developmental systems.

Authors:  Christine Ho; Leonardo Morsut
Journal:  Stem Cell Reports       Date:  2021-05-11       Impact factor: 7.765

5.  Versatile synthesis and rational design of caged morpholinos.

Authors:  Xiaohu Ouyang; Ilya A Shestopalov; Surajit Sinha; Genhua Zheng; Cameron L W Pitt; Wen-Hong Li; Andrew J Olson; James K Chen
Journal:  J Am Chem Soc       Date:  2009-09-23       Impact factor: 15.419

6.  A modified consumer inkjet for spatiotemporal control of gene expression.

Authors:  Daniel J Cohen; Roberto C Morfino; Michel M Maharbiz
Journal:  PLoS One       Date:  2009-09-18       Impact factor: 3.240

7.  Bypassing Glutamic Acid Decarboxylase 1 (Gad1) Induced Craniofacial Defects with a Photoactivatable Translation Blocker Morpholino.

Authors:  Matthew J O'Connor; Lindsey L Beebe; Davide Deodato; Rebecca E Ball; A Tyler Page; Ariel J VanLeuven; Kyle T Harris; Sungdae Park; Vani Hariharan; James D Lauderdale; Timothy M Dore
Journal:  ACS Chem Neurosci       Date:  2018-09-24       Impact factor: 4.418
  7 in total

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