AIM: The current study aims to assess the role of the histological parameters in liver biopsy for explaining the variance of liver stiffness, as well as the performance of transient elastography in quantifying liver fibrosis in patients with chronic hepatitis C. METHODS: 324 consecutive CHC patients were prospectively included in this study. All of them had positive HCV-RNA in serum and had underwent percutaneous liver biopsy for grading and staging the diseases (METAVIR scoring system). All were referred to liver stiffness measurement 1 day prior to biopsy. RESULTS: Liver stiffness values were strongly correlated with fibrosis (r=0.759, p<0.0005). They also correlated with steatosis (r=0.255, p<0.0005), necroinflammatory activity (r=0.378, p<0.0005) and hepatic iron deposition (r=0.143, p=0.03). The univariate regression analysis demonstrated that fibrosis (sq.R=0.610, p<0.0005), activity (sq.R=0.145, p<0.0005) and steatosis (sq.R=0.037, p=0.002) were correlated with liver stiffness. In multiple regression analysis, all three variables independently influenced liver stiffness: fibrosis (p<0.0005), activity (p=0.039) and steatosis (p=0.025). Together they explained 62.4% of the variance of the liver stiffness. The areas under ROC curve for the diagnosis of fibrosis F > or =1, F > or =2, F > or =3, and F=4 were 0.936, 0.862, 0.910 and 0.938, for the cut-off values of 4.9 kPa, 7.4 kPa, 9.1 kPa and 11.85 kPa respectively. CONCLUSIONS: Transient elastography is a useful method for chronic hepatitis C assessment. Fibrosis is the main predictor of liver stiffness, but activity and steatosis also influence liver stiffness.
AIM: The current study aims to assess the role of the histological parameters in liver biopsy for explaining the variance of liver stiffness, as well as the performance of transient elastography in quantifying liver fibrosis in patients with chronic hepatitis C. METHODS: 324 consecutive CHCpatients were prospectively included in this study. All of them had positive HCV-RNA in serum and had underwent percutaneous liver biopsy for grading and staging the diseases (METAVIR scoring system). All were referred to liver stiffness measurement 1 day prior to biopsy. RESULTS:Liver stiffness values were strongly correlated with fibrosis (r=0.759, p<0.0005). They also correlated with steatosis (r=0.255, p<0.0005), necroinflammatory activity (r=0.378, p<0.0005) and hepatic iron deposition (r=0.143, p=0.03). The univariate regression analysis demonstrated that fibrosis (sq.R=0.610, p<0.0005), activity (sq.R=0.145, p<0.0005) and steatosis (sq.R=0.037, p=0.002) were correlated with liver stiffness. In multiple regression analysis, all three variables independently influenced liver stiffness: fibrosis (p<0.0005), activity (p=0.039) and steatosis (p=0.025). Together they explained 62.4% of the variance of the liver stiffness. The areas under ROC curve for the diagnosis of fibrosis F > or =1, F > or =2, F > or =3, and F=4 were 0.936, 0.862, 0.910 and 0.938, for the cut-off values of 4.9 kPa, 7.4 kPa, 9.1 kPa and 11.85 kPa respectively. CONCLUSIONS: Transient elastography is a useful method for chronic hepatitis C assessment. Fibrosis is the main predictor of liver stiffness, but activity and steatosis also influence liver stiffness.
Authors: Meng Yin; Jayant A Talwalkar; Kevin J Glaser; Sudhakar K Venkatesh; Jun Chen; Armando Manduca; Richard L Ehman Journal: AJR Am J Roentgenol Date: 2011-07 Impact factor: 3.959
Authors: Giovanna Ferraioli; Carmine Tinelli; Barbara Dal Bello; Mabel Zicchetti; Raffaella Lissandrin; Gaetano Filice; Carlo Filice; Elisabetta Above; Giorgio Barbarini; Enrico Brunetti; Willy Calderon; Marta Di Gregorio; Roberto Gulminetti; Paolo Lanzarini; Serena Ludovisi; Laura Maiocchi; Antonello Malfitano; Giuseppe Michelone; Lorenzo Minoli; Mario Mondelli; Stefano Novati; Savino F A Patruno; Alessandro Perretti; Gianluigi Poma; Paolo Sacchi; Domenico Zanaboni; Marco Zaramella Journal: World J Gastroenterol Date: 2013-01-07 Impact factor: 5.742